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PULMONOLOGIYA

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No 2 (2011)
https://doi.org/10.18093/0869-0189-2011-0-2

EDITORIAL COLUMN

EDITORIAL

CLINICAL GUIDELINES

REVIEW

93-99 4142
Abstract

ACQ questionnaire as a new tool for assessing control of asthma

ORIGINAL STUDIES

60-63 805
Abstract
Summary.Ventilation scintigraphy of the lungs with analysis of alveolar-capillary permeability (ACP) was performed in patients with confirmed diagnoses of community-acquired pneumonia (CAP, n = 40), infiltrative pulmonary tuberculosis (IPT, n = 20), distal pulmonary embolism (DPE, n = 11),peripheral lung carcinoma (PLC, n = 17), and in 22 healthy volunteers. ACP values were higher in affected and intact lungs in patients with CAP at 10 and 30 min of the investigation vs those with DPE and were higher at 30 min in the affected lung in patients with CAP compared to patients with IPT. Comparison of ACPs in DPE and IPT patients revealed the ACP reduction in affected and intact lungs of DPE patients at 30 min of the investigation. PLC patients demonstrated the ACP reduction in affected lung compared to contralateral lung. Therefore, ACP gave additional information for differential diagnosis of CAP, IPT, DPE and PLC
64-67 5971
Abstract

Summary. Clinical features, drug resistance of Mycobacterium tuberculosis, a course of the disease and treatment efficacy in 210 patients with fibrocavernou tuberculosis of the lung have been presented in this article. The patients were treated in specialized penitentiary settings in Kirov region.Particula attention was paid for the course of complicated fibrocavernous tuberculosis. The later was characterized by severe clinical manifestation, significan drug resistance of M. tuberculosis, lower effectiveness of the therapy and high mortality.

Patients with swear-positive fibrocavernous tuberculosis including those with drug-resistant M. tuberculosis were found to be a persistent source of infection led to worse epidemiologic situation requiring strict isolation of the patients in specialized facilities and a regular control.

75-80 799
Abstract

Summary. We analyzed concentration of matrix metalloproteinase MMP9 and complex MMP9/TIMP1 in blood serum in patients with chronic obstructive pulmonary disease (COPD) and in patients with co-existing COPD and ischemic heart disease (IHD).

Serum concentration of complex MMP9/TIMP1 in patients with COPD was significantly higher than in controls. Patients with COPD stage III had higher concentration of the complex than those with COPD stage II. It is important that MMP9/TIMP1 concentration increased more significantly in patients with combined pathology than in patients with COPD. Difference between MMP9 level in patients with COPD and in patients with co-existing COPD and IHD was estimated. Highest levels of MMP9 were found in patients with combined disease.

Therefore, concentrations of MMP9 and MMP9/TIMP1 positively correlated with COPD severity both in patients with COPD and with combination of COPD and IHD.

81-86 759
Abstract

Summary. COPD affects not only the respiratory system but has systemic effects including peripheral muscle dysfunction, synovial and vascular pathology and depression partly caused by the direct influence of inflammatory mediators. Pulmonary rehabilitation is recognized as a crucial component of management of patients with COPD. This study was performed in Research Institute of Pulmonology of Federal Medical and Biological Agency and evaluated one of rehabilitation methods, namely physical training, in term of its influence on systemic inflammation markers and level of testosterone in COPD patients. The study involved 31 patients with COPD stage III–IV treated with standard drug therapy according to the disease severity. Of them, 16 patients were involved in pulmonary rehabilitation programs. As a result, pulmonary rehabilitation group patients improved 6-min distance by 80 m, FEV1 by 13 % and decreased FRV by 14 % and RV by 30 % from baseline. These parameters did not change or changed non-significantly in patients treated with medications alone. Systemic inflammation and testosterone level were also improved in pulmonary rehabilitation group.

87-91 580
Abstract

Summary.The study investigated duration of treatment effect of monoclonal anti-IgE-antibodies (omalizumab) after discontinuation of the therapy in asthma patients. The study involved 23 patients treated with monoclonal anti-IgE-antibodies. Daytime and nighttime asthma symptoms, need in rescue medications, daily dose of inhaled steroids (ICS) in beclomethasone equivalents, FEV1, allergy skin tests, quality of life according to AQLQ questionnaire, and asthma control level according to GINA, 2006, were analyzed. Patient-reported control of asthma was evaluated using the Asthma Control test (ACTФ). In 2 months after discontinuation of therapy with monoclonal anti-IgE-antibodies, increase in daytime and nighttime asthma symptoms, need in rescue medications and daily doses of ICS, worsening in asthma control, increase in skin hyperreactivity to domestic and epidermal allergens, and decrease in quality of life were found (all statistically significant). Therefore, the results have shown that monoclonal anti-IgE-antibodies could be administered in discrete regimen; this would allow reduction in frequency of the patient's visits to clinic and in cost of treatment.

49-53 809
Abstract

Summary. The study was aimed at investigating the intracranial and cerebral perfusion pressures during lung ventilation in 58 patients with brain insult. The study demonstrated that non-invasive ventilation did not affect the intracranial pressure and cardiovascular activity significantly and therefore did not deteriorate the cerebral perfusion pressure. This confirms a benefit of non-invasive lung ventilation and a rationale for its use for respiratory support incorporated in intensive therapy of acute cerebral vascular failure. A role of monitoring gas content and arteriovenous oxygen difference in the venous blood flow from the cranial cavity was also defined during respiratory support in patients with acute cerebral vascular failure.

PRACTICAL NOTES

109-112 718
Abstract

An experience of administration of inhaled tobramycin in severe nosocomial pneumonia

HEALTHCARE MANAGEMENT

115-118 811
Abstract

Issues of respiratory diseases and possible ways of their resolution in municipal healthcare service

EDUCATION

ERS NEWS

ANNIVERSARIES



ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)