Debatable issues about effects of nanoparticles on respiratory system.

Источник: A.H.Limper, K.S.Knox, G.A.Sarosi et al. Official American Thoracic Society Statement: Treatment of fungal infections in adult pulmonary and critical care patients. Am. J. Respir. Crit. Care Med. 2011; 183: 96–128.

Summary. The aim of this study was to investigate the platelet activity in smokers with chronic obstructive pulmonary disease (COPD). Platelet aggregation was studied using the impedance aggregometer "Chrono-log" with ADP and collagen induction in the whole citrated blood samples. Slowing of early stages of aggregation was seen in patients with COPD. More severe COPD corresponded to more active aggregation. We also evaluated effects of acetylsalicylic acid (Cardiomagnyl) on dyspnea and lung function in patients with COPD.

Summary. Leading specialists (n = 91) of tertiary medical facilities were questioned on drug formulations and dosing of 102 commercially available medications routinely used in COPD. The aim of the surveillance was to determine critically important (essential) and additional (non-essential) medications using VEN-analysis (V – vital; E – essential; N -non-essential). Data of the surveillance were proceeded using an intellectual method. Distribution of drugs through VEN groups resulted in selection of medications effective in COPD. Critically important medication groups for inpatient and outpatient treatment of COPD were also determined.

Summary. Neurovegetative regulation of the cardiorespiratory system was studied in 229 participants (83 healthy persons and 146 patients with bronchial asthma) using the synchronous analysis of heart rhythm and systolic and diastolic blood pressure variability. All participants were divided into groups depending on smoking status. The groups differed in parameters of neurovegetative regulation. More prominent neurovegetative regulatory disorders were found in smokers. Formation of strongly determined regulatory system was shown in patients with bronchial asthma. Smoking led to early quantitative and qualitative remodeling of the regulatory system.

Резюме. Целью исследования было изучение показателей вентиляционной функции легких, а также структурно-функционального состояния правого отдела сердца и кровотока в легочной артерии в сопоставлении с клиническим течением и показателями портальной гемодинамики у больных циррозом печени (ЦП). Установлено, что изменение структурно-функциональных показателей сердца при ЦП зависит от стадии компенсации портальной гипертензии и сопровождается перестройкой параметров внутрисердечной гемодинамики. Выявлено, что у больных ЦП с наличием легочной артериальной гипертензии имеют место вентиляционные нарушения по рестриктивному типу I степени.

Functions of alveolar macrophages and surfactant protein D in lung disease.

Current approach to chemotherapy of pulmonary tuberculosis.

Phenotypes of chronic obstructive pulmonary disease and the ECLIPSE study: preliminary results.

Abilities to achieve stable control of asthma with regard to variability of the disease.

A fatal case of swine flu (А / H1N1 / 09) complicated by generalized nosocomial infection.