Cystic fibrosis phenotype with the complex allele s466x-r1070q in Russian Federation Elena I. Kondrat'eva1
https://doi.org/10.18093/0869-0189-2017-27-6-695-703
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Abstract
The aim of this study was to investigate phenotypic features of cystic fibrosis (CF) in patients carrying the complex allele S466X(TGA)-R1070Q. Methods. Data from CF register of Russian Federation, 2014, were used. The Russian CF register includes data of 2,131 patients from 74 regions of Russian Federation. The complex allele S466X(TGA)-R1070Q was found in 17 patients (the study group) and homozygous F508del mutation was found in 170 patients (the control group). The groups did not differ in main clinical, functional and microbiological parameters. Survival was also investigated. Results. Sweat chloride concentration was higher in the study group patients compared to the control group (116.53 mmol/L vs 102.2 mmol/L; р = 0.0341). There were 11.77% of deaths in a combined group of patients with the complex allele vs 3.53% in homozygous F508del mutation group (р = 0.159). Moreover, no significant difference in survival was found between the groups (p = 0.058). FEV1 was higher in the study group (84.69 ± 17.85%pred. vs 64.95 ± 27.16%pred. in the control group: р = 0.0483). Patients did not differ significantly in percentiles of height, weight, and body mass index. Amyloidosis and pneumothorax were seen in the control group, but not in patients with the complex allele S466X(TGA)-R1070Q. Polyps were diagnosed in 19 (11.17%) of patients with F508del/F508del genotype and were not found in the study group patients. Prevalence of diabetes mellitus and hepatic cirrhosis was similar in both the groups. Osteoporosis was diagnosed in 10% of control patients and in one (5.88%) of the study group patients. Chronic or intermitted Pseudomonas aeruginosa infection and chronic infection of Staphylococcus aureus were equally seen in both the groups, but Burkholderia cepacia сomplex and Stenotrophomonas maltophilia were found more often in the study group patients compared to controls (23.52% vs 10.58% and 11.76% vs 2.35%, respectively). Conclusion. The results of this study confirmed that the complex allele S466X(TGA)-R1070Q has properties of class I mutation and should be considered as a “severe” mutation.
About the Authors
E. I. Kondrat'evaRussian Federation
Elena I. Kondrat'eva, Doctor of Medicine, Professor, Head of Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Head of Department of Cystic Fibrosis, Moscow Regional State Referral Center for Children
N. V. Petrova
Russian Federation
Nika V. Petrova, Doctor of Biology, Chief Scientist, Laboratory of Genetic Epidemiology
S. A. Krasovskiy
Russian Federation
Stanislav A. Krasovskiy, Candidate of Medicine, Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; pneumologist at the 2#nd Pulmonology Department, D.D.Pletnev City Teachingl Hospital, Moscow Healthcare Department; Senior Researcher at Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center
N. Yu. Kashirskaya
Russian Federation
Nataliya Yu. Kashirskaya, Doctor of Medicine, Professor, Principal Researcher, Laboratory of Genetic Epidemiology
S. I. Kutsev
Russian Federation
Sergey I. Kutsev, Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Science, Director
E. K. Ginter
Russian Federation
Evgeniy K. Ginter, Doctor of Biology, Academician of Russian Academy of Science, Academic Advisor
A. V. Polyakov
Russian Federation
Aleksandr V. Polyakov, Doctor of Biology, Professor, Head of DNA Diagnostic Laboratory
E. L. Amelina
Russian Federation
Elena L. Amelina, Candidate of Medicine, Head of Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute
A. Yu. Voronkova
Russian Federation
Anna Yu. Voronkova, Candidate of Medicine, Senior Researcher, Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center; pediatrician at Moscow Regional State Referral Center for Children
V. D. Sherman
Russian Federation
Viktoriya D. Sherman, Candidate of Medicine, Senior Researcher, Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center; pediatrician at Moscow Regional State Referral Center for Children
A. V. Chernyak
Russian Federation
Aleksandr V. Chernyak, Candidate of Medicine, Head of Laboratory of Functional and Ultra-sound Investigations
R. F. Zinchenko
Russian Federation
Rena A. Zinchenko, Doctor of Medicine, Professor, Deputy Director for Science and Clinical Care
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Review
For citations:
Kondrat'eva E.I., Petrova N.V., Krasovskiy S.A., Kashirskaya N.Yu., Kutsev S.I., Ginter E.K., Polyakov A.V., Amelina E.L., Voronkova A.Yu., Sherman V.D., Chernyak A.V., Zinchenko R.F. Cystic fibrosis phenotype with the complex allele s466x-r1070q in Russian Federation Elena I. Kondrat'eva1. PULMONOLOGIYA. 2017;27(6):695-703. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-6-695-703
ISSN 2541-9617 (Online)