Antibiotic-induced oxidative stress and antibiotic resistance
https://doi.org/10.18093/0869-0189-2017-27-5-664-671
Abstract
This is a review of published data on oxidative stress-induced antibiotic resistance of pathogens caused by antimicrobials. Known mechanisms of oxidative stress in a bacterial cell include occurrence of oxygen reactive species, protein oxidation products, fat acids, intracellular molecular oxygen and transition metal ions. Investigations of bacterial antioxidant defense under antibiotic-induced oxidative stress are at an early stage. Understanding the relationship between oxidative stress and bacterial resistance to antibiotics could facilitate development of novel antimicrobials due to both stimulation of oxidation properties of antimicrobials and searching new ways for inhibition of antioxidant defense of pathogens.
About the Authors
L. B. Postnikova
Nizhniy Novgorod Regional City Teaching Hospital No.38
Russian Federation
Russian Federation
Doctor of Medicine, Associate Professor
tel.: 910-390-64-37
ul. Chernyshevskogo 22, Nizhniy Novgorod, 603000, Russia
S. K. Soodaeva
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Doctor of Medicine, Professor, Head of Laboratory of Clinical and Experimental Biophysics
Professor at Department of Human Pathology
tel.: 495-465-52-64
ul. Odinnadtsataya Parkovaya 32, build. 4, Moscow, 105077, Russia
ul. Trubetskaya 8, build. 2, Moscow, 119991, Russia
I. A. Klimanov
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Candidate of Medicine, Senior Researcher at Laboratory of Clinical and Experimental Biophysics
tel.: 495-465-52-64
ul. Odinnadtsataya Parkovaya 32, build. 4, Moscow, 105077, Russia
N. I. Kubysheva
Kazan (Volga region) Federal University, Kazan University the Ministry of education and science of the Russian Federation
Russian Federation
Russian Federation
Doctor of Biology, Senior Researcher of the Research Laboratory "Health Informatics"
tel.: (910) 796-98-38
ul. Kremlevskaja 18, Kazan', 420000, Tatarstan Republic, Russia
K. I. Afinogenov
Federal Teaching Hospital No.123, Federal State Research and Clinical Center of Physical and Chemical Medicine, Federal Medical and Biological Agency of Russia
Russian Federation
Russian Federation
Pulmonologist
tel.: (919) 969-19-90
Krasnogorskoe shosse 15, Odintsovo of Moscow region, 143003, Russia
M. V. Glukhova
I.M.Sechenov First Moscow State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Postgraduate student at Department of Human Pathology
tel.: (985) 641-17-63
ul. Trubetskaya 8, build. 2, Moscow, 119991, Russia
L. Yu. Nikitina
Khanty-Mansiyskaya State Medical Academy
Russian Federation
Russian Federation
Doctor of Medicine, Head of Department of Therapy
tel.: 908-882-86-20
ul. Mira 40, Khanty-Mansiysk, 628007, Russia
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Review
For citations:
Postnikova L.B., Soodaeva S.K., Klimanov I.A., Kubysheva N.I., Afinogenov K.I., Glukhova M.V., Nikitina L.Yu. Antibiotic-induced oxidative stress and antibiotic resistance. PULMONOLOGIYA. 2017;27(5):664-671. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-5-664-671
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