Does a combined vaccine against respiratory infection contribute to functional improvement in patients with chronic obstructive pulmonary disease?

The aim of this study was to compare functional status of patients with chronic obstructive pulmonary disease (COPD) vaccinated by combined vaccine vs single vaccine against influenza and a control group. Methods. The study involved 170 patients with COPD stage I to IV. Of them, 50 patients were vaccinated with a combined vaccine against pneumococcus, Haemophilus influenzae type b and influenza; 80 patients with equal COPD severity were not vaccinated and were treated with basic therapy; 20 COPD patients were vaccinated with a single vaccine against influenza, and 20 COPD patients were not vaccinated. Lung function and physical tolerability at 6-min walk test were assessed at baseline and in 12 months. Results. A significantly higher FEV1 (57.4 ± 2.0 % vs 50.4 ± 2.8 %) was found in COPD patients vaccinated with a combined vaccine compared to unvaccinated COPD patients; the difference between baseline FEV1 and FEV1 in 12 months after vaccination was 3.5 % vs 2.11 %, respectively. The improvement in 6-min distance was + 34 m (+ 7.4 %) in combined vaccine group compared to + 13 m (+ 3.7 %) in influenza vaccine group. Conclusion. COPD patients vaccinated with a combined vaccine against bacterial pathogens plus influenza better improved their lung function and physical tolerability compared to COPD patients vaccinated with a single vaccine against influenza.

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