FEATURES OF NEUTROPHILIC GRANULOCYTE CHEMILUMINESCENT ACTIVITY IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA
https://doi.org/10.18093/0869-0189-2014-0-3-62-67
Abstract
Aim. The aim of the study was to investigate luminol-dependent and lucigenin-dependent neutrophil granulocyte chemiluminescence in patients with community-acquired pneumonia (CAP).
Methods. Forty-eight patients with moderate CAP and 40 patients with severe CAP were examined during two-week treatment. Primary and secondary reactive oxygen species (ROS) production was investigated using the chemiluminescence assay.
Results. Patients with moderate CAP maintained a high-level ROS production for 2 weeks of the treatment; a trend towards improving neutrophil functional activity was seen after 7 days of the treatment. In patients with severe CAP superoxide radical production improved to the end of the study, whereas secondary ROS synthesis remained elevated during the entire treatment period with slowing secondary ROS accumulation rate to the end of the study which adversely affected neutrophilic granulocyte reactivity.
Conclusion. Thus, neutrophil granulocyte chemiluminescence disorders as well as clinical risk factors could be considered as predictors of severe CAP.
Methods. Forty-eight patients with moderate CAP and 40 patients with severe CAP were examined during two-week treatment. Primary and secondary reactive oxygen species (ROS) production was investigated using the chemiluminescence assay.
Results. Patients with moderate CAP maintained a high-level ROS production for 2 weeks of the treatment; a trend towards improving neutrophil functional activity was seen after 7 days of the treatment. In patients with severe CAP superoxide radical production improved to the end of the study, whereas secondary ROS synthesis remained elevated during the entire treatment period with slowing secondary ROS accumulation rate to the end of the study which adversely affected neutrophilic granulocyte reactivity.
Conclusion. Thus, neutrophil granulocyte chemiluminescence disorders as well as clinical risk factors could be considered as predictors of severe CAP.
About the Authors
A. A. Savchenko
Federal Institution Research Institute for Medical Problems of the North Siberian Branch of the Russian Academy of Medical Science; Krasnoyarsk, Russia
State Institution V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, the Healthcare Ministry of Russia; Krasnoyarsk, Russia
Russian Federation
Russian Federation
L. B. Dresvyankina
Federal Institution Research Institute for Medical Problems of the North Siberian Branch of the Russian Academy of Medical Science; Krasnoyarsk, Russia
Russian Federation
Russian Federation
Yu. I. Grinshteyn
State Institution V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, the Healthcare Ministry of Russia; Krasnoyarsk, Russia
Russian Federation
Russian Federation
A. I. Aristov
State Institution V.F.Voyno-Yasenetskiy Krasnoyarsk State Medical University, the Healthcare Ministry of Russia; Krasnoyarsk, Russia
Russian Federation
Russian Federation
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Review
For citations:
Savchenko A.A., Dresvyankina L.B., Grinshteyn Yu.I., Aristov A.I. FEATURES OF NEUTROPHILIC GRANULOCYTE CHEMILUMINESCENT ACTIVITY IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA. PULMONOLOGIYA. 2014;(3):62-67. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-3-62-67
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