Recurrent respiratory papillomatosis with lung involvement and malignant transformation
https://doi.org/10.18093/0869-0189-2022-32-2-261-269
Abstract
Recurrent respiratory papillomatosis (RP) is one of the most challenging benign tumors of the upper and lower respiratory tract. Dissemination of the tumor process and damage to the lung tissue not only increase the likelihood of malignancy, but also complicate the choice of treatment tactics, largely limit the surgical options, and necessitate a multidisciplinary approach.
Methods. The enrolled patients with RP have been treated (n = 190) in the Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University”, Ministry of Healthcare of Russian Federation, from 2000 to the present. Changes in the lung tissue were detected in 5 (2.6%) patients (2 men and 3 women) with aggressive course of the disease.
Results. The clinical characteristics of patients and the outcomes of lung damage in RP are presented. Four patients had malignant transformation of the tumor into verrucous carcinoma of the upper third of the trachea with invasion into the soft tissues of the neck (n = 1) or malignant degeneration of the lesion in the lung parenchyma (n = 3).
Conclusion. The presented rare observations suggest polymorphism of clinical and radiological symptoms of papillomatous damage to the tracheobronchial system and lungs.
About the Authors
M. A. Ryabova
Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Marina A. Ryabova, Doctor of Medicine, Professor, Department of Otorhinolaryngology
ul. L`va Tolstogo 6–8, Saint-Petersburg, 197022, Russia
V. P. Molodtsova
Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Valentina P. Molodtsova, Doctor of Medicine, Endoscopist, Department of Thoracic Surgery, Research Institute of Surgery and Emergency Medicine
ul. L`va Tolstogo 6–8, Saint-Petersburg, 197022, Russia
G. V. Portnov
Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Gleb V. Portnov, Candidate of Medicine, Otorhinolaryngologist, Department of Otorhinolaryngology, Research Institute of Surgery and Emergency Medicine
ul. L`va Tolstogo 6–8, Saint-Petersburg, 197022, Russia
A. L. Akopov
Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Russian Federation
Andrey L. Akopov, Doctor of Medicine, Professor, Head of the Department of Thoracic Surgery, Research Institute of Surgery and Emergency Medicine
ul. L`va Tolstogo 6–8, Saint-Petersburg, 197022, Russia
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Review
For citations:
Ryabova M.A., Molodtsova V.P., Portnov G.V., Akopov A.L. Recurrent respiratory papillomatosis with lung involvement and malignant transformation. PULMONOLOGIYA. 2022;32(2):261-269. (In Russ.) https://doi.org/10.18093/0869-0189-2022-32-2-261-269
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