Quality of life in bronchial asthma patients: influence of nedocromil sodium (tilade)
Abstract
The aim of this research was the estimation of quality of life in bronchial asthma patients before and after 3 month treatments with anti-inflammatory antiasthmatic agent — nedocromil sodium (Tilade). 20 patients with mild and moderate BA were investigated by routine clinical and functional tests, content of total IgE assessed. For assessing of quality of life E.Juniper’s Asthma Quality of Life Questionnaire (AQLQ), and short and simple AQ20 (F.H. Quirk, P .W .Jones, 1994) questionnaires were used. Tilade has been prescribed 2 puffs twice daily corresponding to a daily dosage of 8 mg nedocromil sodium. Tilade led to a significant reduction in the incidence of asthma attacks and cough, wakening in the night due to dyspnoe. During treatment with tilade improvement and normalisation of bronchial patency revealed. Tilade decreased the blood level of total IgE. Thus, nedocromil sodium (tilade) was finding in patients with mild and moderate asthma as the effective antiasthmatic drug, which improve quality of life in asthma patients.
About the Authors
N. N. BrimkulovKyrgyzstan
Zh. Duisenova
Kyrgyzstan
A. D. Kalieva
Kyrgyzstan
References
1. Сенкевич Н.Ю., Белевский А.С., Чучалин А.Г. Оценка влияния образовательных программ в пульмонологии (Астма-школ) на качество жизни больных бронхиальной астмой (первый опыт применения в России опросника SF-36 в пульмонологии) / / Пульмонология.— 1997.— № 3 .— С. 18—22.
2. Шмелев Е.И., Беда М.В., Jones P.W., Twaites R., Чучалин А.Г. Качество жизни больных хроническими обструктивными болезнями легких / / Там ж е.— 1998. № 2.— С.79—81.
3. De Jong J.W., Postma D.S., de Monchy J.G.R., Koeter G.H. A review of nedocromil sodium in asthma therapy / / Eur. Respir. Rev.— 1993.— V ol.3.— P.511—519.
4. Engstrom С.-P., Persson L.-O ., Larsson S., Sullivan M . Reliability and vilidity of a Swedish version of the St. G eorge’s Respiratory Questionnaire / / Eur. Respir. J.— 1998.— Vol. 11.— P.61—66.
5. Global Initiative for Asthma. Global Strategy for Asthma M anagement and Prevention N H L B I/W H O Workshop Report. N I H / NHLBI 1995, Publication № 95— 3659, 176p.
6. Jones P.W. Quality of life m easurem ent in asthma: an editorial / / Eur. Respir. J.— 1995.— V0I.8.— P .885—887.
7. Jones P.W. Testing health status (“quality of life”) questionnaires for asthma and COPD / / Ibid.— 1998.— Vol. 11.— P.5—7.
8. Juniper E., Guyatt G.H., Epstein R.S. et al. Evaluation of impairment of health related quality of life in asthma: development of a questionaire for use in clinical trials / / Thorax.— 1992.— Vol.47.— P.76—83.
9. Kalieva A.D., Musaeva K.M., Brimkulov N.N. Validation of Russian version of AQ20 quality of life questionaires in asthma patients / / Eur. Respir. J.— 1998.— V ol.12, Suppl.28.— P.440s.
10. Konig P. Clinical overview of nedocromil sodium / / Allergy Proc.— 1995.— Vol. 16.— P.73—76.
11. Quirk F.H., Jones P.W. Repeatability of two new short airways questionnaires / / Thorax.— 1994.— Vol.49.— P.1075P.
12. White E.A., Jones P.W. Cross-sectional validation of a short and simple measure of quality of life for routine use in asthma / / Thorax.— 1995,— Vol.50, Suppl.2.— P.22.
13. White E.A., Jones P.W. Cross-sectional and longitudinal validation of a short and simple measure of quality of life in asthma / / Am. J. Respir. Crit. Care M ed.— 1996.— V ol.513, № 4 .— Suppl.2.— P.A754.
Review
For citations:
Brimkulov N.N., Duisenova Zh., Kalieva A.D. Quality of life in bronchial asthma patients: influence of nedocromil sodium (tilade). PULMONOLOGIYA. 1999;(2):50-53. (In Russ.)