The use of the home sympathomimetic venttocol for treatment of severe exacerbation of chronic obstructive pulmonary disease
Abstract
The open comparative study of efficacy of two drugs — Gen-Salbitamol (Gen-Pharma, Canada) and Salgim (VNC BAV — Russia) for treatment of severe exacerbation of chronic obstructive pulmonary disease (COPD) was carried out. Two groups of COPD patients which were comparable in demographic and functional parameters received Gen-Salbutamol and Salgim correspondingly in the same doses — 2.5 mg via compressor nebulizer “Pulmo-Neb” (DeVilbiss, USA). The efficacy of the drugs was evaluated by external breathing parameters, peak volume flow, subjective intensity of dyspnea according to the visual analogue scale, gas and electrolyte arterial blood analysis. The mean FEV1 increase for patients received Gen-Salbutamol was 16.9% in 60 min. and 18.7%for the second group. The maximum PVF meanings were registered in 120— 180 min. After inhalation of both of drugs. There was not statistically significant difference between all the parameters in the equal periods of time in both of groups (p>0.05). The adverse effects (tremor, tachycardia, headache, dryness in oral cavity) were observed in both of groups with the same frequency and did not require to abolish the drug or to be corrected. The clinical efficacy of those two drugs was quite the equal. Thus, they can be used successfully for the treatment of COPD exacerbation.
About the Authors
S. N. Avdeev
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. S. Sokolov
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
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Review
For citations:
Avdeev S.N., Sokolov A.S., Chuchalin A.G. The use of the home sympathomimetic venttocol for treatment of severe exacerbation of chronic obstructive pulmonary disease. PULMONOLOGIYA. 1999;(2):24-30. (In Russ.)
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