Morphofunctional peculiarities of bronchial asthma in different aged patients
Abstract
Age peculiarities of symptoms, airway morphological and functional status, respiratory APUD cell activity and biogenic monoamines (BMA) (serotonin, epinephrine and norepinephrine) concentration in bronchial mucous membrane (BM) were studied in 205 bronchial asthma patients 15 to 83 years old. The controls were 75 healthy persons of different age. Morphological and functional disorders were detected using radiological methods (chest X-ray examination, CT scan, scintigraphy), fiberoptic bronchoscopy, Doppler-echocardiography and spirometry. Respiratory APUD cell activity was assessed evaluating neuron-specific enolasa (NCE) concentration, which is a marker of APUD cells, in bronchial lavage fluid using immune enzyme assay. An amount of BMA in BM biopsy specimens was determined with the Falk—Hillarp histochemical procedure. Correlation analysis allowed to discover an interrelationship between age BM injury, pulmonary microcirculation impairment, bronchial passability disorders, occurrence of pulmonary emphysema and, on the other hand, the APUD cell activity and certain BMA concentration in BM.
About the Authors
A. Z. Kuzmin
Муниципальное медицинское учреждение городская поликлиника № 2;
Медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
V. I. Trofimov
Муниципальное медицинское учреждение городская поликлиника № 2;
Медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
Kuzmin A.Z., Trofimov V.I. Morphofunctional peculiarities of bronchial asthma in different aged patients. PULMONOLOGIYA. 2002;(5):52-58. (In Russ.)
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