Evaluation of conservative and operative treatment of lung abscesses considering immune disorders

Abstract

During an examination and management of 431 lung abscess patients a preoperative programme was elaborated taking into account the stage of the process (the 1^st group – an exacerbation, the 2^nd group – the process stabilization, the 3^rd group – a stable condition) and an endotoxicosis degree, immune and hormonal status as well. The 1^st group patients were differentially administered immune correctors (parenteral, endobronchial, or topic), Dalargin, arachidonic acid metabolites inhibitors; the abscesses were treated with sorbents. Such management was effective and allowed to avoid the operation in 181 (63.07%) of 287 the 1^st group patients, while only 14 (11.48%) of the 2^nd group patients and 8 (36.36%) of the 3^rd group patients were treated without the operation. A significant standardizing effect on the immune system was achieved against the background of the process localization and stabilization. This fact permitted diminishing the surgical intervention in 218 (95.61%) patients of 228 operated. We observed postoperative complications in 16.04% of the 1^st group cases against 22.22% in the 2^nd group and 28.57% in the 3^rd group. This also confirms the effectiveness of the developed preoperative programme.