An ultrastructural observation of lungs treated by the hypoxic therapy: an assessment of its therapeutic efficacy as one of the impulse therapy
Abstract
Intermittent hypoxic training (IHT) has been used for prevention and treatment of some diseases and for training athletes. In this study, we examined the morphological changes in lungs after IHT using light and electron microscopy. 39 male Wistar rats were sustained intermittent hypoxic training (10 % 0 2) for 5 min three times a day with 5-m in rebreathing intervals or 15, 30, 60 min once a day for 21 consecutive days, respectively. Results showed that pulmonary dam age occurred at 3-rd day of IHT, but one week later the pulmonary dam age repaired in IHT animals with brief-time hypoxia (5 or 15 min), but 30-m in and 60-m in IHT groups showed pulmonary dam age until 21- st day. Ultrastructurely, lungs in 5-m in and 15-m in IHT groups were characterized by hyperplasia of alveolar type II cells, which may enable them more rapid repairing of hypoxic lesions and may represent a key mechanism of the IHT. Those findings dem onstrate that IHT could be justified as the impulse therapy for the cells and tissues.
About the Authors
Kodo Okuyama
Клиническая исследовательская лаборатория терапии Торным воздухом"
Japan
Japan
Jingtao Jiang
Центральный институт электронно-микроскопических исследований, Медицинская школа Ниппон
Japan
Japan
Kaoru Aihara
Центральный институт электронно-микроскопических исследований, Медицинская школа Ниппон
Japan
Japan
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Review
For citations:
Okuyama K., Jiang J., Aihara K. An ultrastructural observation of lungs treated by the hypoxic therapy: an assessment of its therapeutic efficacy as one of the impulse therapy. PULMONOLOGIYA. 2004;(4):67-71. (In Russ.)
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