A ROLE OF PROINFLAMMATORY CYTOKINES IL-17, IL-18 AND TNF-A IN PULMONARY AND INTRACARDIAC HAEMODINAMIC DISORDERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.18093/0869-0189-2014-0-1-32-37
Abstract
Chronic obstructive pulmonary disease (COPD) is frequently complicated by secondary pulmonary hypertension and development of chronic cor pulmonale. Serum concentrations of IL-17, IL-18 and TNF-a were investigated in patients with stable COPD of different stages. A statistically significant increase in serum cytokine concentrations was found in COPD patients in comparison to healthy individuals. Moreover, significant direct correlations were found between serum cytokine concentrations, on the one hand, and the mean pulmonary artery pressure and the right heart dimensions, on the other hand. The results of the study suggest a possible role of IL-17, IL-18 and TNF-a in the pathogenesis of COPD, pulmonary hypertension and chronic cor pulmonale.
About the Authors
M. V. Boldina
ГБОУ ВПО "Нижегородская государственная медицинская академия": 603005, Нижний Новгород, пл. Минина и Пожарского, 10 / 1
Russian Federation
Russian Federation
L. B. Postnikova
Городской пульмонологический консультативный центр ГБУЗ НО "Городская больница № 28": 603040, Нижний Новгород, ул. Чаадаева, 7
Russian Federation
Russian Federation
N. I. Kubysheva
НИИ молекулярной биологии и региональной экологии ГОУ ВПО "Нижегородский государственный университет им. Н.И.Лобачевского": 603005, Нижний Новгород, ул. Ошарская, 8д
Russian Federation
Russian Federation
S. K. Soodaeva
ФГБУ "НИИ пульмонологии" ФМБА России: 105077, Россия, Москва, ул. 11-я Парковая, 32, корп. 4
Russian Federation
Russian Federation
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Review
For citations:
Boldina M.V., Postnikova L.B., Kubysheva N.I., Soodaeva S.K. A ROLE OF PROINFLAMMATORY CYTOKINES IL-17, IL-18 AND TNF-A IN PULMONARY AND INTRACARDIAC HAEMODINAMIC DISORDERS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. PULMONOLOGIYA. 2014;(1):32-37. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-1-32-37
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