Ventilation disorders and arterial stiffness indicators in patients with chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2020-30-2-184-191
Abstract
The aim of the study was to identify the correlation between ventilation disorders of the lungs and the development of arterial stiffness in patients with chronic obstructive pulmonary disease (COPD).
Methods. The following parameters were evaluated in the patients (n = 61) enrolled in the study: spirometry, bodyplethysmography, cardiac-ankle vascular index (CAVI) and an ancho-brachial vascular index. Additionally, the pulse wave propagation velocity was calculated in the area from the ostium of the aorta to the infragenicular arteries.
Results. According to the study results, a direct correlation, characterized by moderate to noticeable strength, was found between the parameters of pulmonary ventilation (bronchial resistance, intrathoracic gas volume, residual lung volume (RLV), total lung capacity (TLC), RLV/TLC) and the CAVI parameter, characterizing vascular stiffness on the section from the aorta ostium to the infragenicular arteries. It was shown that the best method for assessing changes in blood vessels is CAVI, which is independent of the level of blood pressure at the moment of the study.
Conclusion. It has been established that if there is a correlation between impaired ventilation and arterial stiffness, the systemic nature of the lesion in COPD is confirmed, which explains the high incidence of cardiovascular diseases in patients with COPD.
About the Authors
D. A. Punin
Smolensk State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Postgraduate Student of the Department of Therapy, Ultrasound and Functional Diagnostics of Faculty of Postgraduate Physician Training,
ul. Krupskoy 28, Smolensk, 214019
V. A. Milyagin
Smolensk State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Doctor of Medicine, Professor, Head of the Department of Therapy, Ultrasound and Functional Diagnostics of Faculty of Postgraduate Physician Training,
ul. Krupskoy 28, Smolensk, 214019
O. A. Kovaleva
Smolensk State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Postgraduate Student of the Department of Therapy, Ultrasound and Functional Diagnostics of Faculty of Postgraduate Physician Training,
ul. Krupskoy 28, Smolensk, 214019
References
1. Noteboom B., Jenkins S., Maiorana A. et al. Comorbidities and medication burden in patients with chronic obstructive pulmonary disease attending pulmonary rehabilitation. J. Cardiopulm. Rehabil. Prev. 2014; 34 (1): 75–79. DOI: 10.1097/HCR.0000000000000036.
2. García-Olmos L., Alberquilla A., Ayala V., et al. Comorbidity in patients with chronic obstructive pulmonary disease in family practice: a cross sectional study. BMC Fam. Pract. 2013; 14: 11. DOI: 10.1186/1471-2296-14-11.
3. Divo M., Cote C., de Torres J.P. et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2012; 186 (2): 155–161. DOI: 10.1164/rccm.201201-0034OC.
4. McGarvey L.P., John M., Anderson J. A. et al. Ascertainment of cause-specific mortality in COPD: operations of the TORCH Clinical Endpoint Committee. Thorax. 2007; 62 (5): 411–415. DOI: 10.1136/thx.2006.072348.
5. Weber T., Auer J., O'Rourke M.F. et al. Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation. 2004; 109 (2): 184–189. DOI: 10.1161/01.CIR.0000105767.94169.E3.
6. Meaume S., Benetos A., Henry O.F. et al. Aortic pulse wave velocity predicts cardiovascular mortality in subjects > 70 years of age. Arterioscler. Thromb. Vasc. Biol. 2001; 21 (12): 2046–2050. DOI: 10.1161/hq1201.100226.
7. Fisk M., Cheriyan J., Mohan D. et al. Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease. Respir. Res. 2018; 19: 100. DOI: 10.1186/s12931-018-0792-1.
8. Vanfleteren L.E., Spruit M.A., Groenen M.T. et al. Arterial stiffness in patients with COPD: the role of systemic inflammation and the effects of pulmonary rehabilitation. Eur. Respir. J. 2014; 43 (5): 1306–1315. DOI: 10.1183/09031936.00169313.
9. Fisk M., McEniery C.M., Gale N. et al. Surrogate markers of cardiovascular risk and chronic obstructive pulmonary disease: a large case-controlled study. Hypertension. 2018; 71 (3): 499–506. DOI: 10.1161/HYPERTENSIONAHA.117.10151.
10. McAllister D.A., Maclay J.D., Mills N.L. et al. Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2007; 176 (12): 1208–1214. DOI: 10.1164/rccm.200707-1080OC.
11. Meaume S., Rudnichi A., Lynch A. et al. Aortic pulse wave velocity as a marker of cardiovascular disease in subjects over 70 years old. J. Hypertens. 2001; 19 (5): 871–877. DOI: 10.1097/00004872-200105000-00006.
12. Sun C.K. Cardio-ankle vascular index (CAVI) as an indicator of arterial stiffness. Integr. Blood Press. Control. 2013; 6: 27–38. DOI: 10.2147/IBPC.S34423.
13. Kim B., Takada K., Oka S., Misaki T. Influence of blood pressure on cardio-ankle vascular index (CAVI) examined based on percentage change during general anesthesia. Hypertens. Res. 2011; 34: 779–783. DOI: 10.1038/hr.2011.31.
14. Shirai K., Utino J., Otsuka K., Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J. Atheroscler. Thromb. 2006; 13 (2): 101–107. DOI: 10.5551/jat.13.101.
15. Savushkina O.I., Chernyak A.V., ed. [Pulmonary function tests: from theory to practice: Practical handbook]. M.: STROM; 2017 (in Russian).
16. Brodskaya T.A., Gel'tser B.I., Nevzorova V.A. [Arterial stiffness and respiratory diseases (pathophysiological mechanisms and clinical significance)]. Vladivostok: Dal'nauka; 2008 (in Russian).
17. Makarova M.A., Avdeev S.N., Chuchalin A.G. [Hypoxemia as a potential risk factor of endothelial dysfunction and arterial stiffness in patients with chronic obstructive pulmonary disease]. Pul'monologiya. 2013; (3): 36–40. DOI: 10.18093/0869-0189-2013-0-3-36-40 (in Russian).
18. Mamaeva M.G., Sobko E.A., Kraposhina A.Y. et al. [Clinical and pathogenic aspects of arterial stiffness and the left heart remodeling in patients with chronic obstructive pulmonary disease and coronary artery disease]. Pul'monologiya. 2014; (5): 5–10. DOI: 10.18093/0869-0189-2014-0-5-5-10 (in Russian).
19. Matsui H., Ihara Y., Fujio Y. et al. Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κB and NF-IL6 in cardiac myocytes. Cardiovasc. Res. 1999; 42 (1): 104–112. DOI: 10.1016/S0008-6363(98)00285-5.
20. Gaynitdinova V.V., Avdeev S.N. [Large peripheral vessel remodeling in patients with chronic obstructive pulmonary disease and in hypertension co-morbidity]. Pul'monologiya. 2015; 25 (1): 50–57. DOI: 10.18093/0869-0189-2015-25-1-50-57 (in Russian).
Review
For citations:
Punin D.A., Milyagin V.A., Kovaleva O.A. Ventilation disorders and arterial stiffness indicators in patients with chronic obstructive pulmonary disease. PULMONOLOGIYA. 2020;30(2):184-191. (In Russ.) https://doi.org/10.18093/0869-0189-2020-30-2-184-191
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