The findings of a study of reactogenic and clinical effects of a polycomponent vaccine derived from conditionally pathogenic microorganisms for immunotherapy of patients with chronic obstructive lung disease a represented. The vaccine was administered by a combined intranasal subcutaneous method (3 to 4 intranasal and 5 to 6 subcutaneous injections). 26 patients with chronic obstructive lung disease, mostly complicated by infectious allergic bronchial asthma were observed. 16 of those had severe, 8 — moderate, and 2 — mild disease. It was demonstrated that policomponent vaccine was characterized by low reactogenity. Antibody titers to vaccine components significantly increased as a result of immunotherapy. The clinical effectivity was defined by the change of disease gravity, duration of remission, possible reduction of initial medication; presence or absence of cough or sputum, auscultative findings, lung function parameters.

The immunotherapy of 26 patients had positive effect in 18 (69,2 %) of them, up to 2 months effect in 4, and no effect in 4 (15,4 %). The use of polycomponent vaccine increases the opportunities of therapeutic impact on those severe cases.

A comprehensive study of cardio respiratory system with the use of spirometry, local pulmonary reography, defining diffusion capacity tests, echocardiogrphy and ergospirometry has been carried out among 47 normals and 91 patients with chronic bronchitis in order to work out a method of forecasting a potential level of physical capacity.

It has been established that physical capacity of patients with chronic bronchitis is determined by the functional indicators of airway obstruction, the level of MVV and lung diffusion capacity at rest.

Static parameters of lung function, ventilation-perfusion ratio, parameters of heart pumping function taken at rest come secondary when defining the physical capacity level.

Practical recommendations on defining the physical capacity forecast have been given on the basis of linear regression equation.

A method of comprehensive medication-free treatment for treatment-rehabilitation units of day-time hospitals, outpatient polyclinics and sanatoriums was offered for the respiratory patients. The following rooms were allocated: artificial micro-climate, ray therapy and reflexotherapy, respiratoty rooms, along with traditional rooms for aerosol inhalations, endobronchial drainage, therapeutic physical training, massage etc.

Statistically significant results of positive clinical effect of each suggested technique a represented, the appropriate technical devices are recommended.

Disodium chromoglycate particles were labelled with pure gamma-radiator, 99m Tc, using the co-precipitation technique based on spray drying. Radioactive drug particles were mixed, with lactose carrier and filled into hard gelatin capsules. Seven healthy volunteers inhaled drug doses using Spinhaler, I. S. F., Berotec, and Rotahaler dry powder devices. The fractional deposition of drug particles in the upper airways and lung region were monitored using a gamma camera. The fraction of the dose relained in the powder inhaler was the smallest for I. S. F. and especially for Berotec inhalers. These devices have narrower air channel constructions with a smaller wall surface area than the Spinhaler and Rotahaler devices. Thus the sticking of the drug particles onto the plastic walls was less probable for the first mentioned devices. The drug particles from all the dry powder inhalers seemed to be more able to follow the inspired air stream without depositing in the upper airways than previously documented for pressurized metered dose aerosols. I. S. F. and Berotec inhalers with narrow air channels gave the greatest lung deposition of the inhaled drug, particles. Thus the design of the dry powder inhaler was noticed to have a remark able effect both on the emptying of the capsules as well as on the redispersion of the powder mixture.

Airway response to spontaneous submaximal isocapnic hyperventilation with cold dry air (IHCA) was studied in normal sybjects and patients with chronic non-specific lung diseases. Change of bronchial patency after IHCA in chronic bronchitis was not different from control subjects. Considerable bronchospasm was observed in subjects with bronchial asthma inoluding its earliest stages. IHCA challenge can be used in clinical pracrice to detect airway hyperreactivity.