E-rosette formation by low-density (LDE) and high-density (HDE) eosinophils was studied in sheep erythrocytes. The group of patients revealed a 4— 17 times greater quantity of LDE than the healthy group. HDE demonstrated a much smaller difference. The very high rosette-forming capacity of LDE in the patient group exceeded that of the control group 11 - to 24-fold. Incubation of patients’ LDE with adrenalin and obsidan revealed tolerance of adrenergic stimulation and blockade. The rosette-forming capacity of patients’ HDE did not differ spectacularly from the control group’s, though its HDE incubation with adrenalin resulted in a stronger suppression of rosette formation, while the adrenergic blockade considerably increased the number of rosette-forming eosinophils. Patients’ native serum demonstrated a capacity to strongly increase the quantity of rosette-forming HDE in healthy persons. This capacity was far greater pronounced in BA patients. BA and atopic dermatitic patients revealed a more pronounced abnormality of eosinophilic characteristics, while these numerical and qualitative characteristics in chronic opisthorchiatic patients were somewhere in between the sick and healthy groups.

Changes of static lung volumes and airflow limitations were studied in 49 bronchial asthmatic patients after a 100 mg intravenous trental infusion and two-week trental monotherapy (600 mg per os daily). Bronchial resistance after an acid test was reduced in 14 patients (frequency 0.28) — a broncholithic effect; and rose in another 15 (frequency 0.31) — a bronchospastic effect. The other twenty cases did not reveal shifts beyond the scope of reproducibility. These changes were unstable, and reduced bronchial resistance persisted with only 11 patients (frequency 0.23) 1.5 hours later. Irrespective of the nature of bronchial resistance changes, the clinical manifestations of the obstructive syndrome after an acid test did not offer any noticeable changes. Two-week trental monotherapy reduced airflow limitation in 17 patients, judging by bodyplethysmographic and spirometric tests, while 37 patients revealed a positive clinical effect, with obstructive syndrome symptoms reduced. As no interdependence was revealed between the dynamics of airflow limitations and the clinical signs of obstructive syndrome, we can ascribe the positive curative effect of trental on BA patients to its anti-inflammatory properties, rather than bronchoactive.

We studied the clinical efficiency of a beta-2-agonist, whose manufacture was recently launched in Russia on the basis of saventol, a salbutamol derivative, in the treatment of 31 patients affected with chronic obstructive pulmonary diseases. Based in Taimyr, an Arctic Russian peninsula, the studies revealed a high broncholithic efficiency of the preparation, its bronchodilatation index exceeding 29%. Electronic paramagnetic resonance tests revealed selective effects of saventol on intracellular metabolism, which promoted the normalisation of the recuperative oxidation process. Fluorescent probe studies of patients after saventol treatment revealed an improvement of certain physico-chemical characteristics of erythrocytic membranes.

We studied the phagocytic activity of alveolar macrophages and neutrophils in the peripheric blood and bronchoalveolar lavage fluid (BALF) in 37 patients affected with chronic obstructive bronchitis (COB) and healthy persons to determine the activity of elastase and collagenase in BALF cells and their supernate.
The peripheric blood of COB patients revealed normal neutrophilic and monocytic phagocytosis, while the monocytes of complementary pulmonary emphysematous patients revealed an increased absorbing activity.
BALF demonstrated an acute depression of alveolar macrophagal phagocytosis, which a remission of the inflammatory process raised close to normal only with persons not affected with pulmonary emphysema. COB patients revealed increased activities of elastase and collagenase both in an acute inflammatory process and during remissions. COB patients not affected with pulmonary emphysema displayed the greatest activity increase of elastase.

25 while male rats of no breed were subjected to gradual total cooling from +5 to -15 degrees Centigrade every day for 5 weeks, six hours a day, to study the stereoultrastructural surface epithelium arrangement of the trachea and major bronchi. Our research singled out and allowed to characterise three stages of the adaptive compensatory reaction of the respiratory tract epithelium: adaptive tension, stabilisation and adaptation.

This study intended to elaborate an erythrocytic model approach to diagnosis of drug sensibilisation through an evaluation of lipid peroxidation and the electrophoretic mobility of erythrocytes.
The contact of erythrocytes with causal drugs resulted in a major increase of dien conjugate levels and an increased percentage of erythrocytes with a high electrophoretic mobility.
The erythrocytic model revealed effects of the causal drug even in patients taking glucocorticoids.

Out of the 75 cases of pulmonary histiocytosis X from Langerhans’ cells under study, the diagnosis found morphological proof in 54. Alongside cytological and hystological tests, we also recurred to electronic microscopic studies, and cell immunotyping with KP-1 (CD-68), MAC-387, and S-100 protein — specific markers of histiocytosis X. This diagnosis is considered proved only when specific markers (Birbeck bodies) and/or the characteristic immunochemical markers of Langerhans’ cells — KP-1 (CD-68) and S-100 protein — are identified in the macrophages of lesion sites.

The state of lymphocytes’ β-adrenoreceptors was examined for 26 healthy children during their first three years of life and for 143 infants with the obstructive bronchitis. The study concerned the activity of adrenodependant intracellular biochemical processes. Certain decrease of lymphocytes’ glycogenolysis activity obviously correlating with the disease severity and duration was revealed. The restoration of β2 -adrenoreceptors activity in lymphocytes during the treatment with the p2 -adrenoagonists was marked. The data makes it possible to consider that β2 -adrenoreceptors desensitization is typical for infants with an obstructive bronchitis. The diagnostic test complex is proposed for making a decision on the type of a medicamental therapy for the children with obstructive bronchitis.

The acupuncture effect mechanisms (efficacy of a single procedure and a treatment course) have been thoroughly studied with due account of neirophysical, biochemical and energetic aspects. The study was based on an integral estimation assessment of patients’ conditions (contemporary European and classic Chinese estimates) for 60 patients with a mild course of bronchial asthma and 30 patients with the pre-asthma state treated with acupuncture monotherapy.
Specific aspects of the homeostasis adaptive correction have been defined. This makes it possible to recommend the acupuncture not only for treatment but for the bronchial asthma prophylaxis.