1. Blanco I., Diego I., Bueno P. et al. Geographical distribution of COPD prevalence in Europe, estimated by an inverse distance weighting interpolation technique. Int. J. Chron. Obstruct. Pulmon. Dis. 2017; 13: 57-67. https://doi.org/10.2147/COPD.S150853.
2. Chuchalin A.G., Khaltaev N., Antonov N.S. et al. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation. Int. J. Chron. Obstruct. Pulmon. Dis. 2014; 9: 963-974. https://doi.org/10.2147/COPD.S67283.
3. Global Initiative for Chronic Obstructive Pulmonary Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. 2018 Report. © 2018 Global Initiative forChronic Obstructive Lung Disease, Inc. Available at: http://goldcopd.org/wp-content/uploads/2016/04/GOLD-2018-WMS.pdf
4. Feldman G.J., Sousa A.R., Lipson D.A. et al. Comparative efficacy of once-daily umeclidinium/vilanterol and tiotropium/olodaterol therapy in symptomatic chronic obstructive pulmonary disease: a randomized study. Adv. Ther. 2017; 34 (11): 2518-2533. https://doi.org/10.1007/s12325-017-0626-4.
5. Российское респираторное общество. Обновленный проект клинических рекомендаций: Хроническая обструктивная болезнь легких. 2016. Доступно по: http://spulmo.ru/obrazovatelnye-resursy/federalnye-klinicheskie-rekomendatsii [Дата обращения 12.02.2018]. / Russian Respiratory Society. Updated Project of Clinical Guidelines: Chronic Obstructive Pulmonary Disease. 2016. Available at: http://spulmo.ru/obrazovatelnye-resursy/federalnye-klinicheskie-rekomendatsii (in Russian).
6. Rodrigo G.J., Price D., Anzueto A. et al. LABA/LAMA combinations versus LAMA monotherapy or LABA/ICS in COPD: a systematic review and meta-analysis. Int. J. Chron. Obstruct. Pulmon. Dis. 2017; 12: 907-922. https://doi.org/10.2147/COPD.S130482.
7. Wedzicha J.A., Zhong N., Ichinose M. et al. Indacaterol/glycopyrronium versus salmeterol/fluticasone in Asian patients with COPD at a high risk of exacerbations: results from the FLAME study. Int. J. Chron. Obstruct. Pulmon. Dis. 2017; 12: 339-349. https://doi.org/10.2147/COPD.S125058.
8. Calzetta L., Rogliani P., Matera M.G., Cazzola M. A systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable COPD. Chest. 2016; 149 (5): 1181-1196. https://doi.org/10.1016/j.chest.2016.02.646.
9. Schlueter M., Gonzalez-Rojas N., Baldwin M. et al. Comparative efficacy of fixed-dose combinations of long-acting muscarinic antagonists and long-acting β2-agonists: a systematic review and network meta-analysis. Ther. Adv. Respir. Dis. 2016; 10 (2): 89-104. https://doi.org/10.1177/1753465815624612.
10. Sion K.Y.J., Huisman E.L., PunekarIan Y. S. et al. A network meta-analysis of long-acting muscarinic antagonist (LAMA) and long-acting β2-agonist (LABA) combinations in COPD. Pulm. Ther. 2017; 3: 297-316. https://doi.org/10.1007/s41030-017-0048-0.
11. Calzetta L., Ora J., Cavalli F. et al. Impact of LABA/LAMA combination on exercise endurance and lung hyperinflation in COPD: a pair-wise and network meta-analysis. Respir. Med. 2017; 129: 189-198. https://doi.org/10.1016/j.rmed.2017.06.020.
12. Bateman E.D., Ferguson G.T., Barnes N. et al. Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study. Eur. Respir. J. 2013; 42 (6): 1484-1494. https://doi.org/10.1183/09031936.00200212.
13. Buhl R., Maltais F., Abrahams R. et al. Tiotropium and olodaterol fixed-dose combination versus mono-components in COPD (GOLD 2-4). Eur. Respir. J. 2015; 45 (4): 969-979. https://doi.org/10.1183/09031936.00136014.
14. Miravitlles M., Chapman K.R., Chuecos F. et al. The efficacy of aclidinium/formoterol on lung function and symptoms in patients with COPD categorized by symptom status: a pooled analysis. Int. J. Chron. Obstruct. Pulmon. Dis. 2016; 11: 2041-2053. https://doi.org/10.2147/COPD.S114566.
15. Kerwin E., Ferguson G.T., Sanjar S. et al. Dual bronchodilation with indacaterol maleate/glycopyrronium bromide compared with umeclidinium bromide/vilanterol in patients with moderate-to-severe COPD: Results from two randomized, controlled, cross-over studies. Lung. 2017; 195 (6): 739-747. https://doi.org/10.1007/s00408-017-0055-9.
16. Donohue J.F. Minimal clinically important differences in COPD lung function. COPD; 2005; 2 (1): 111-124.
17. Cazzola M., MacNee W., Martinez F.J. et al. ATS/ERS Task Force. Outcomes for COPD pharmacological trials: from lung function to biomarkers. Eur. Respir. J. 2008; 31 (2): 416-468. https://doi.org/10.1183/09031936.00099306.
18. Jones P.W., Beeh K.M., Chapman K.R. et al. Minimal clinically important differences in pharmacological trials. Am. J. Respir. Crit. Care Med. 2014; 189 (3): 250-255. https://doi.org/10.1164/rccm.201310-1863PP.
19. Chapman K.R., Beeh K.M., Beier J. et al. A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: the GLOW5 study. BMC Pulm. Med. 2014; 14: 4. https://doi.org/10.1186/1471-2466-14-4.
20. Feldman G., Maltais F., Khindri S. et al. A randomized, blinded study to evaluate the efficacy and safety of umeclidinium 62.5 μg compared with tiotropium 18 μg in patients with COPD. Int. J. COPD. 2016; 11 (1): 719-730. https://doi.org/10.2147/COPD.S102494.
21. Agustí A., de Teresa L., De Backer W. et al. A comparison of the efficacy and safety of once-daily fluticasone furoate/vilanterol with twice-daily fluticasone propionate/salmeterol in moderate to very severe COPD. Eur. Respir. J. 2014; 43 (3): 763-772. https://doi.org/10.1183/09031936.00054213.
22. Ichinose M., Fujimoto T., Fukuchi Y. Tiotropium 5 μg microg via Respimat and 18 μg microg via HandiHaler; efficacy and safety in Japanese COPD patients. Respir. Med. 2010; 104 (2): 228-236. https://doi.org/10.1016/j.rmed.2009.11.011.
23. Points to consider on switching between superiority and non-inferiority. The European Agency for the Evaluation of Medicinal Products: Evaluation of Medicines for Human Use. London, 27 July 2000. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003658.pdf
24. Westwood M., Bourbeau J., Jones P.W. et al. Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. Respir. Res. 2011; 12: 40. https://doi.org/10.1186/1465-9921-12-40.
25. Zider A.D., Wang X., Buhr R.G. et al. Reduced COPD exacerbation risk correlates with improved FEV1: a meta-regression analysis. Chest. 2017; 152 (3): 494-501. https://doi.org/10.1016/j.chest.2017.04.174.
26. Tashkin D.P., Rennard S.I., Martin P. et al. Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial. Drugs. 2008; 68 (14): 1975-2000.
27. García-Río F., Soler-Cataluña J.J., Alcazar B. et al. Requirements, strengths and weaknesses of inhaler devices for COPD patients from the expert prescribers' point of view: Results of the EPOCA Delphi consensus. COPD. 2017; 14 (6): 573-580. https://doi.org/10.1080/15412555.2017.1365120.
28. Ciciliani A.M., Langguth P., Wachtel H. In vitro dose comparison of Respimat® inhaler with dry powder inhalers for COPD maintenance therapy. Int. J. Chron. Obstruct. Pulmon. Dis. 2017; 12: 1565-1577. https://doi.org/10.2147/COPD.S115886.
29. Molimard M., Raherison C., Lignot S. et al. Chronic obstructive pulmonary disease exacerbation and inhaler device handling: real-life assessment of 2935 patients. Eur. Respir. J. 2017; 49: 1601794. https://doi.org/10.1183/13993003.01794-2016.
30. van der Palen J., Thomas M., Chrystyn H. et al. A randomised open-label cross-over study of inhaler errors, preference and time to achieve correct inhaler use in patients with COPD or asthma: comparison of ELLIPTA with other inhaler devices. NPJ Prim. Care Respir. Med. 2016; 26: 16079. https://doi.org/10.1038/npjpcrm.2016.79.