Macroelement and microelement composition of mediastinal lymph nodes of patients with sarcoidosis
https://doi.org/10.18093/0869-0189-2017-27-6-754-759
Abstract
This study was aimed at measuring concentrations and investigation of relationships between macro- and microelements in mediastinal lymph nodes of patients with sarcoidosis. Methods. The study involved 28 patients (50% were males; median age, 42.5 (23; 53) years) with confirmed diagnosis of sarcoidosis. Autopsy samples from 13 individuals died from occasional causes (41.2% were males; median age, 43 (38.7; 61.3) years) were used for comparison. The groups did not differ in age and gender. Neutron activation analysis was used to investigate chemical elements in mediastinal lymph node tissue samples. Results. Concentrations of Ca, Cr, Fe, Co, Zn, Rb, Sb, Cs, Ba, Eu, Lu, Yb, Hf, Th, and U in the lymph node tissue of patients with sarcoidosis were increased, and concentration of zinc was decreased compared to control samples. Concentrations of Sm, Au, Sr, Nd, As, Br, Ag, Tb, Sc, Ta, Na, and La did not differ between the groups. Direct relationships were found in element groups Fe-Cr-Sb-Ca, Fe-U-Th, Co-U-Th, U-Cr, Th-Br, Sc-Zn, Eu-La, and Ce-Lu.
About the Authors
O. A. Denisova
Federal Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Ol'ga A. Denisova, Assistant Lecturer, Department of Hospital Internal Medicine with the Course of Physical Rehabilitation and Sport Medicine
Moskovskiy tract 2, Tomsk, 634050, Russia
G. E. Chernogoryuk
Federal Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Georgiy E. Chernogoryuk, Doctor of Medicine, Professor, Department of Hospital Internal Medicine with the Course of Physical Rehabilitation and Sport Medicine
Moskovskiy tract 2, Tomsk, 634050, Russia
N. V. Baranovskaya
Federal Tomsk State Research Technical University, Ministry of Education and Scienc
Russian Federation
Russian Federation
Natal'ya V. Baranovskaya, Doctor of Biology, Professor, Department of Geoecology and Geochemistry
prospect Lenina 30, Tomsk, 634050, Russia
L. P. Rikhvanov
Federal Tomsk State Research Technical University, Ministry of Education and Scienc
Russian Federation
Russian Federation
Leonid P. Rikhvanov, Doctor of Geology and Mineralogy, Professor, Department of Geoecology and Geochemistry
prospect Lenina 30, Tomsk, 634050, Russia
G. M. Chernyavskaya
Federal Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Galina M. Chernyavskaya, Doctor of Medicine, Professor, Department of Hospital Internal Medicine with the Course of Physical Rehabilitation and Sport Medicine
Moskovskiy tract 2, Tomsk, 634050, Russia
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Review
For citations:
Denisova O.A., Chernogoryuk G.E., Baranovskaya N.V., Rikhvanov L.P., Chernyavskaya G.M. Macroelement and microelement composition of mediastinal lymph nodes of patients with sarcoidosis. PULMONOLOGIYA. 2017;27(6):754-759. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-6-754-759
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