A modeling of tobacco smoking and smoke and resin microparticles deposition in the airways
https://doi.org/10.18093/0869-0189-2017-27-5-643-649
Abstract
The aim of this study was smoking modeling with visualization of microparticles of the smoke deposed on the walls of the digestive and the respiratory tracts.
Methods. Patients with tuberculosis and chronic non-infectious lung diseases participated in the study. All the patients underwent bronchoscopy. Powdered tantalum mircoparticles with the size of < 1 µm were used as markers of tobacco smoke microparticle deposition. The tantalum powder was administered orally and intratracheally. Tantalum microparticles deposed in the airways were identified using the chest X-ray examination immediately and in 4 h after the insufflation.
Results. In most patients (64.3%), 95% of microparticles deposed in the mouth, the oropharingeal area, the pharynx, the pyriform sinuses and the larynx just after the insufflation and only 5% achieved the lower airways.
Conclusion. We investigated factors facilitating deposition of microparticles into the bronchi. Such deposition could lead to bronchial obstruction and further penetration of microparticles into the alveoli. We also determined three types of optical density of the deposed smoke microparticles that could characterize microparticle layer thickness, a mechanism of deposition (impaction, sedimentation, or diffusion) and its distinct location.
Keywords
About the Authors
A. A. Krishtafovich
Saint-Petersburg Federal Research Institute of Phthisiology and Pulmonology, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Doctor of Medicine, Senior Researcher, Academic Advisor, Radiological Division
tel.: (812) 772-13-60
Ligovskiy pr. 2–4, Saint-Petersburg, 191036, Russia
B. M. Ariel'
Saint-Petersburg City State Pathological Bureau
Russian Federation
Russian Federation
Doctor of Medicine, Professor, Member of Council Board of Saint-Petersburg Pathological Service
tel.: (812) 513-60-98
Uchebnyy per. 5, Saint Petersburg, 194354, Russia
References
1. Arzhenovskiy S.V. Social and economic determinants of smoking in Russia. Kvantil'. 2006; 1: 81–100 (in Russian).
2. Brodskaya T.A., Nevzorova V.Ya., Gel'tser B.I., et al. Experimental modeling of smoking-related chronic obstructive lung diseases with vascular dysfunction. Byulleten' SO RAMN. 2009; 1 (135): 60–65 (in Russian).
3. Mestecky J., Lamm M.E., McGhee J.R., Bienenstock J., Mayer L., Strobel H.W. (eds.). Mucosal Immunology. San Diego, CA: Elsever Science Inc.; 2005.
4. Krishtafovich A.A., Puchkova T.V. An evaluation of functional activity of bronchial mucosa in tuberculosis and other pulmonary diseases. Problemy tuberkuleza i drugikh zabolevaniy legkikh. 2003; 10: 17–20 (in Russian).
5. Tager I.B., Speizer F.E. Risk estimates for chronic bronchitis in smokes: a study of male female differences. Am. Rev. Respir. 1976; 116: 619–625.
6. Sapin M.R., Nikityuk V.B., Shadlinskiy D.B., Movsumov T.N. Small glands of digestive and respiratory systems. Elista: Dzhangar; 2001 (in Russian).
7. Krishtafovich A.A., Ariel' B.M. Exocrine gland cysts in tracheal and bronchial walls. Pul'monologiya. 2014; (3): 99–102. DOI: 10.18093/0869-0189-2014-0-3-99-102 (in Russian).
8. Аrcavi L., Benovitz N.L. Cigarette smoking and infection. Arch. Intern. Med. 2004; 164 (20): 2206–2016. DOI: 10.1001/archinte.164.20.2206.
Review
For citations:
Krishtafovich A.A., Ariel' B.M. A modeling of tobacco smoking and smoke and resin microparticles deposition in the airways. PULMONOLOGIYA. 2017;27(5):643-649. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-5-643-649
Views:
1531
Email this article 