Vitamin D deficiency as a risk factor of uncontrolled asthma
https://doi.org/10.18093/0869-0189-2017-27-5-624-628
Abstract
The aim of this study was to determine a relationship between IL-17, IL-10 and vitamin D concentrations and asthma control level in adult patients.
Methods. This was a comparative study which involved 79 asthma patients. The patients were divided in two groups: 48 patients with good control of asthma (mean age, 52 ± 13 years; BMI, 24.9 (21.6 – 28.3) kg/m2) and 31 patients with uncontrolled asthma (mean age, 57.6 ± 7.9 years; BMI, 29.1 (27.3 – 33.6) kg/m2). Concentrations of IL-10, IL-17 and vitamin D were measured in blood serum using ELISA assay.
Results. Vitamin D concentration was significantly lower in patients with uncontrolled asthma compared to well-controlled asthma. An inverse relationship was found between vitamin D and IL-17 blood concentrations but not between vitamin D and IL-10 blood concentrations.
Conclusion. Serum concentration of vitamin D could be used as a predictor of asthma course and control.
About the Authors
V. I. Kupaev
Samara State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Doctor of Medicine, Professor, Head of Department of Family Medicine
tel.: 927-256-09-27
Chapaevskaya ul. 89, Samara, 443099, Russia
M. S. Nurdina
Samara State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
PhD student, Department of Family Medicine
tel.: 917-824-07-79
Chapaevskaya ul. 89, Samara, 443099, Russia
L. V. Limareva
Samara State Medical University, Healthcare Ministry of Russia
Russian Federation
Russian Federation
Assistant Professor, Leading Researcher, Institute of Experimental Medicine and Biotechnologies
tel.: 905-017-89-92
Chapaevskaya ul. 89, Samara, 443099, Russia
References
1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. 2016 update. Available at: www.ginasthma.org
2. Nagatkin D.A. Effects of sublingual immune therapy on asthma control level. Aspirantskiy vestnik Povolzh'ya. 2013; (5-6): 53–56 (in Russian).
3. Drobik O.S., Biteeva D.V. Uncontrolled asthma: ways to resolve the problem. Astma i allergologiya. 2013; (4): 11–18 (in Russian).
4. Budnevskiy A.V., Chernov A.V., Ermolova A.V., Tribuntseva L.V. Bronchial asthma with co-morbid metabolic syndrome: opportunity to achieve control of the disease. Pul'monologiya. 2014; (5): 39–45. DOI: 10.18093/0869-0189-2014-0-5-39-45 (in Russian).
5. Nenasheva N.M. Federal clinical guidelines on diagnosis and therapy of bronchial asthma, 2016: what is new? Prakticheskaya pul'monologiya. 2016; (3): 3–10 (in Russian).
6. Allain T.J., Dhesi J. Hypovitaminosis D in older adults. Gerontology. 2003; 49 (5): 273–278. DOI: 10.1159/000071707.
7. Wenzel S.E. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 2012; 18 (5): 716–725. DOI: 10.1038/nm.2678.
8. Kurbacheva O.M., Zhestkov A.V., Nagatkin D.A. et al. Current view of immunopathogenesis of bronchial asthma. Rossiyskiy allergologicheskiy zhurnal. 2016; (2): 10–14 (in Russian).
9. Dimitrov V., White J.H. Species-specific regulation of innate immunity by vitamin D signaling. J. Steroid. Biochem. Mol. Biol. 2016; 164: 164–253. DOI: 10.1016/j.jsbmb.2015.09.016.
10. Teske K.A., Bogart J.W., Sanchez L.M. et al. Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites. Eur. J. Med. Chem. 2016; 109: 238–246. DOI: 10.1016/j.ejmech.2016.01.002.
11. Shalaby Samaha H. M., Elsaid A. R., NasrEldin E. Vitamin D and markers of airway inflammation in asthma. Egypt. J. Chest Dis. Tuber. 2015; 64 (4): 779–783. DOI: 10.1016/j.ejcdt.2015.03.027.
12. Prietl B., Treiber G., Pieber T.R., Amrein K. Vitamin D and immune function. Nutrients. 2013; 5 (7): 2502–2521. DOI: 10.3390/nu5072502
Review
For citations:
Kupaev V.I., Nurdina M.S., Limareva L.V. Vitamin D deficiency as a risk factor of uncontrolled asthma. PULMONOLOGIYA. 2017;27(5):624-628. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-5-624-628
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