An association between TLR1 and TLR6 gene polymorphism and development of bronchial asthma
https://doi.org/10.18093/0869-0189-2017-27-5-607-613
Abstract
The aim of this study was to analyze an association between TLR1 and TLR6 gene polymorphism and development of bronchial asthma in Russian patients living at the Republic of Bashkortostan.
Methods. We investigated DNA samples of unrelated individuals (n = 179) and healthy volunteers (n = 121) of Russian ethnic group. DNA was extracted by phenol-chlorophorm extraction. Genotyping of polymorphic variant was performed by the real-time polymerase chain reaction.
Results. An association between rs5743571 polymorphism in the TLR1 gene and rs5743794 polymorphism in the TLR6 gene with occurrence of bronchial asthma has been found.
Conclusion. TLR1 and TLR6 genes are important for asthma susceptibility in Russian population. Polymorphism in rs5743571*C allele and rs5743571*CC genotype of TLR1 gene could be used as high-risk markers; rs5743571*CT genotype of this polymorphic variant could be used as low-risk marker of asthma occurrence. These results can improve our knowledge on defensive mechanisms against atopic sensitization including TLR2 heterodimers and subsequent development of atopic asthma.
About the Authors
G. F. Gimalova
Federal Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Science
Russian Federation
Russian Federation
Candidate of Biology, Researcher, Laboratory of Human Molecular Genetics
tel.: (347) 235-60-88
pr. Oktyabrya 71, Ufa, 450054, Republic of Bashkortostan, Russia
A. S. Karunas
Federal Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Science
Bashkir State University
Russian Federation
Russian Federation
Doctor of Biology, Candidate of Medicine, Professor, Deputy Director for Science
Department of Genetics and Basic Medicine
tel.: (347) 235-60-88
pr. Oktyabrya 71, Ufa, 450054, Republic of Bashkortostan, Russia
ul. Z.Validi 32, Ufa, 450076, Republic of Bashkortostan, Russia
Yu. Yu. Fedorova
Federal Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Science
Russian Federation
Russian Federation
Researcher, Laboratory of Human Molecular Genetics
tel.: (347) 235-60-88
pr. Oktyabrya 71, Ufa, 450054, Republic of Bashkortostan, Russia
Sh. Z. Zagidullin
Bashkir State Medical University
Russian Federation
Russian Federation
Doctor of Medicine, Professor, Head of Department of Propaedeutics of Internal Diseases
tel.: (347) 237-71-14
ul. Lenina 3, Ufa, 450000, Republic of Bashkortostan, Russia
E. I. Etkina
Bashkir State Medical University
Russian Federation
Russian Federation
Doctor of Medicine, Professor, Head of Department of Pediatric Diseases
tel.: (347) 223-11-71
ul. Lenina 3, Ufa, 450000, Republic of Bashkortostan, Russia
E. K. Khusnutdinova
Federal Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Science
Bashkir State University
Russian Federation
Russian Federation
Doctor of Biology, Professor, Academician of Academy of Science, Republic of Bashkortostan; Acting Director
Head of Department of Genetics and Basic Medicine
tel.: (347) 235-60-88
pr. Oktyabrya 71, Ufa, 450054, Republic of Bashkortostan, Russia
ul. Z.Validi 32, Ufa, 450076, Republic of Bashkortostan, Russia
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Review
For citations:
Gimalova G.F., Karunas A.S., Fedorova Yu.Yu., Zagidullin Sh.Z., Etkina E.I., Khusnutdinova E.K. An association between TLR1 and TLR6 gene polymorphism and development of bronchial asthma. PULMONOLOGIYA. 2017;27(5):607-613. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-5-607-613
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