About a role of particle pollution for pathogenesis of chronic lung diseases
https://doi.org/10.18093/0869-0189-2017-27-3-404-409
Abstract
Authors analyzed recently published data and own study results on influence of particulate matter (PM) of different size, origin and chemical composition on the human respiratory system. Traffic-related air pollution is particularly dangerous as it contains transition metals. Short-term exposure of high concentrations of fine particles was associated with an increase in number of hospitalizations and mortality from chronic lung diseases. Long-term exposure of such particles was associated with development of chronic obstructive pulmonary disease, asthma, and lung carcinoma. PM-induced oxidative stress is the key trigger of inflammation. Reactive oxygen species stimulate production and release of cytokines from the cells including bronchial and the lung tissues. The oxidative stress can change the epithelial cell permeability that leads to DNA damage, lipid peroxidation, protein modification, and other disturbances, which facilitate development of chronic lung diseases. There is a need to systematize the available results and better understand the role of PM air pollution for pathogenesis of the respiratory diseases.
About the Authors
Alla F. Kolpakova
Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science
Russian Federation
Doctor of Medicine, Professor, Leading Researcher, Laboratory of Bioinformatics, Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science; tel.: (913) 521-61-02
Russian Federation
Doctor of Medicine, Professor, Leading Researcher, Laboratory of Bioinformatics, Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science; tel.: (913) 521-61-02
Ruslan N. Sharipov
Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science;
Novosibirsk State University, Healthcare Ministry of Russia
Russian Federation
a software endineer, Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science; Senior Lecturer, Novosibirsk State University, Healthcare Ministry of Russia; tel.: (923) 119-35-60
Russian Federation
a software endineer, Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science; Senior Lecturer, Novosibirsk State University, Healthcare Ministry of Russia; tel.: (923) 119-35-60
Fedor A. Kolpakov
Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science
Russian Federation
Candidate of Biology, Head of laboratory of Bioinformatics, Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science; tel.: (913) 943-16-49;
Russian Federation
Candidate of Biology, Head of laboratory of Bioinformatics, Federal State Institute of Computing Technology, Siberian Department of Russian Academy of Science; tel.: (913) 943-16-49;
References
1. Hamra G.B., Guha N., Cohen A. et al. Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ. Health Perspect. 2014; 122 (9): 906–911. DOI: 10.1289/ehp.1408092.
2. Kumar P., Morawska L., Birmili W. et al. Ultrafine particles in cities. Environ. Int. 2014; 66: 1–10. DOI: 10.1016/j.envint.2014.01.013.
3. Veremchuk L.V., Cherpak N.A., Gvozdenko T.A., Volkova M.V. Effects of air pollution on respiratory morbidity in Vladivostok. Zdorov'e. Meditsinskaya ekologiya. Nauka. 2014; (1): 4–6 (in Russian).
4. Veremchuk L.V., Yan'kova V.I., Vyatkina T.I. et al. The atmospheric air pollution as a systemic interaction process of environmental factors. Zdorov'e. Meditsinskaya ekologiya. Nauka. 2015; 61 (3): 35–42 (in Russian).
5. Revich B.A., Shaposhnikov D.A., Avaliani S.L. et al. Change in the atmospheric air quality in Moscow in 2006 – 2012 and risks for the population health. Problemy ekologicheskogo monitoringa i modelirovaniya ekosistem. 2015; 26 (1): 91–122 (in Russian).
6. Falcon-Rodriguez C.I., Osornio-Vargas A.R., Sada-Ovalle I., Segura-Medina P. Aeroparticles, composition, and lung diseases. Front. Immunol. 2016; 7: 3. DOI: 10.3389/fimmu.2016.00003.
7. Samoli E., Stafoggia M., Rodopoulou S. et al. Associations between fine and coarse particles and mortality in Mediterranean cities: results from the MED-PARTICLES Project. Environ. Health Perspect. 2013; 121 (8): 932–938. DOI: 10.1289/ehp.1206124.
8. Simoni M., Baldacci S., Maio S. et al. Adverse effects of outdoor pollution in the elderly. J. Thorac. Dis. 2015; 7 (1): 34–45. DOI: 10.3978/j.issn.2072-1439.2014.12.10.
9. The State Report of the Ministry of Environmental Resources and Ecology of Russian Federation ‘About the environmental control in Russian Federation in 2013’. Available at: http://www.ecogosdoklad.ru/default.aspx (in Russian).
10. Rakhmanin Yu.A., Mikhaylova R.I. Environment and health: priorities of preventive medicine. Gigiena i sanitariya. 2014; 93 (5): 5–10 (in Russian).
11. Lyapunova E.V., Popova I.V., Petrov B.A., Belyakov V.A. Effects of air pollution on prevalence of asthma symptoms in children. Gigiena i sanitariya. 2011; 2: 38–41 (in Russian).
12. Simonova I.N., Antonyuk M.V. A role of technogenic air pollution on development of respiratory diseases. Zdorov'e. Meditsinskaya ekologiya. Nauka. 2015; 1 (59): 14–20 (in Russian).
13. Xing Y.F., Xu Y.H., Shi M.H., Lian Y.X. The impact of PM2.5 on the human respiratory system. J. Thorac. Dis. 2016; 8 (1): e69–74. DOI: 10.3978/j.issn.2072-1439.2016.01.19.
14. Franck U., Odeh S., Wiedensohler A. et al. The effect of particle size on cardio-vascular disorders – the smaller the worse. Sci. Total Environ. 2011; 409 (20): 4217–4221. DOI: 10.1016/j.scitotenv.2011.05.049.
15. Nemmar A., Beegam S., Yuvaraju P. et al. Interaction of amorphous silica nanoparticles with erythrocytes in vitro: role of oxidative stress. Cell. Physiol. Biochem. 2014; 34 (2): 255–265. DOI: 10.1159/000362996.
16. Simonova I.N. and Vyatkina T.I. Effects of air nanoparticles on the respiratory system. Byulleten' fiziologii i patologii dykhaniya. 2013; 49: 115–120 (in Russian).
17. Lodovici M., Bigagli E. Oxidative stress and air pollution exposure. J. Toxicol. 2011; 2011: 487074. DOI: 10.1155/2011/487074.
18. Levanchuk A.V. Ambient air pollution caused by car and road wear. Gigiena i sanitariya. 2014; 93 (6): 17–21 (in Russian).
19. Sarnat S.E., Winquist A., Schauer J.J. et al. Fine particulate matter components and emergency department visits for cardiovascular and respiratory diseases in the St. Louis, Missouri-Illinois, Metropolitan Area. Environ. Health Perspect. 2015; 123 (5): 437–444. DOI: 10.1289/ehp.1307776.
20. Golokhvast K.S., Khristoforova N.K., Chernyshev V.V. et al. Vehicle exhaust gaz composition. Problemy regional'noy ekologii. 2013; (6): 95–101 (in Russian).
21. Cortez-Lugo M., Ramírez-Aguilar M., Pérez-Padilla R. et al. Effect of personal exposure to PM2.5 on respiratory health in a Mexican panel of patients with COPD. Int. J. Environ. Res. Public Health. 2015; 12 (9): 10635–10647. DOI: 10.3390/ijerph120910635.
22. Xu Q., Li X., Wang S. et al. Fine particulate air pollution and hospital emergency room visits for respiratory disease in urban areas in Beijing, China, in 2013. PLoS One. 2016; 11 (4): e0153099. DOI: 10.1371/journal.pone.0153099.
23. Li M.H., Fan L.C., Mao B. et al. Short-term exposure to ambient fine particulate matter increases hospitalizations and mortality in COPD: A systematic review and meta-analysis. Chest. 2016; 149 (2): 447–458. DOI: 10.1378/chest.15-0513.
24. Ni L., Chuang C.C., Zuo L. Fine particulate matter in acute exacerbation of COPD. Front. Physiol. 2015; 6: 294. DOI: 10.3389/fphys.2015.00294.
25. Wu S., Ni Y., Li H. et al. Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in Beijing, China. Environ. Int. 2016; 94: 76–82. DOI: 10.1016/j.envint.2016.05.004.
26. Adam M., Schikowski T., Carsin A.E. et al. Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. Eur. Respir. J. 2015; 45 (1): 38–50. DOI: 10.1183/09031936.00130014.
27. Rice M.B., Ljungman P.L., Wilker E.H. et al. Long-term exposure to traffic emissions and fine particulate matter and lung function decline in the Framingham heart study. Am. J. Respir. Crit. Care Med. 2015; 191 (6): 656–664. DOI: 10.1164/rccm.201410-1875OC.
28. Wong S.L., Coates A.L., To T. Exposure to industrial air pollutant emissions and lung function in children: Canadian Health Measures Survey, 2007 to 2011. Health Rep. 2016; 27 (2): 3–9.
29. Nishimura K.K., Galanter J.M., Roth L.A. et al. Early-life air pollution and asthma risk in minority children: the GALA II and SAGE II studies. Am. J. Respir. Crit. Care Med. 2013; 188 (3): 309–318. DOI: 10.1164/rccm.201302-0264OC.
30. Ermakov N.V. Medical and economic aspects of ecoprevention of childhood atopic asthma and other non-infectious respiratory diseases and socially significant diseases caused by the air pollution in Moscow population. Prakticheskaya pul'monologiya. 2014; (1): 11–14 (in Russian).
31. International Agency for Research on Cancer, World Health Organization. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Trichloroethylene, tetrachloroethylene, and some other chlorinated agents. Lyon, France; 2014. Vol. 106.
32. Raaschou-Nielsen O., Beelen R., Wang M. et al. Particulate matter air pollution components and risk for lung cancer. Environ. Int. 2016; 87: 66–73. DOI: 10.1016/j.envint.2015.11.007.
33. Kolpakova A.F. Current view on mechanisms of hazardous effects of the air pollution on the respiratory system. In: Kolpakova A.F., Gorbunov N.S., and Burgart T.V. Clinical and Morphological Features of Chronic Obstructive Pulmonary Disease in Males. Krasnoyarsk: KrasGMU; 2011: 38–59 (in Russian).
34. Kolpakova A.F., Simkin Yu.Ya., Kolpakov F.A. Ambient Air Pollution and the Lower Respiratory Tract Diseases. Krasnoyarsk: SibGTU; 2008 (in Russian).
35. Jomova K., Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology. 2011; 283 (2–3): 65–87. DOI: 10.1016/j.tox.2011.03.001.
36. Cachon B.F., Firmin S., Verdin A. et al. Proinflammatory effects and oxidative stress within human bronchial epithelial cells exposed to atmospheric particulate matter (PM(2.5) and PM(>2.5)) collected from Cotonou, Benin. Environ. Pollut. 2014; 185: 340–351. DOI: 10.1016/j.envpol.2013.10.026.
37. Zhou B., Liang G., Qin H. et al. p53-Dependent apoptosis induced in human bronchial epithelial (16-HBE) cells by PM(2.5) sampled from air in Guangzhou, China. Toxicol. Mech. Methods. 2014; 24 (8): 552–559.
38. Andreau K., Leroux M., Bouharrour A. Health and cellular impacts of air pollutants: from cytoprotection to cytotoxicity. Biochem. Res. Int. 2012; 2012: 493894. DOI: 10.1155/2012/493894.
39. Li R., Kou X., Geng H. et al. Mitochondrial damage: An important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. J. Hazard. Mater. 2015; 287: 392–401. DOI: 10.1016/j.jhazmat.2015.02.006.
40. Jones M.G., Richeldi L. Air pollution and acute exacerbations of idiopathic pulmonary fibrosis: back to miasma? Eur. Respir. J. 2014; 43 (4): 956–959. DOI: 10.1183/09031936.00204213.
41. Sullivan J.P., Minna J.D., Shay J.W. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev. 2010; 29 (1): 61–72.
42. Soodaeva S.K., Nikitina L.Yu., Klimanov I.A. Mechanisms of oxidative stress mediated by ambient air pollutants: potential ways for the antioxidant defense. Pul'monologiya. 2015; 25 (6): 736–742. DOI: 10.18093/0869-0189-2015-25-6-736-742 (in Russian).
43. Szabo E., Mao J.T., Lam S. et al. Chemoprevention of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013; 143 (5, Suppl.): e40S–60S.
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For citations:
Kolpakova A.F., Sharipov R.N., Kolpakov F.A. About a role of particle pollution for pathogenesis of chronic lung diseases. PULMONOLOGIYA. 2017;27(3):404-409. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-3-404-409
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