Three-component model of pulmonary mechanical activity
https://doi.org/10.18093/0869-0189-2017-27-3-398-403
Abstract
The article provides a review of key studies of the hypothesis about an independent pulmonary mechanical activity: from phylogenic analysis of respiratory movements in amphibians and mammals to respiratory mechanics research. The airflow interruption method revealed negative elastic lung hysteresis. Given the basic physical laws (the first and the second laws of thermodynamics), this paradox was considered as evidence of the independent mechanical activity of the lungs. Predominance of breathing-related pressure fluctuations in an obstructed bronchus over the intrathoracic pressure amplitude was considered as a manifestation of the regional pulmonary mechanical activity. Experimental studies of respiratory mechanics allowed formulation a hypothesis about three levels of pulmonary mechanical activity. The integral pulmonary mechanical activity provides inspiratory and expiratory movements. Smooth muscles of the bronchial wall keep the bronchial lumen during expiration and preclude valvular obstruction of the bronchus (the second level of the mechanical activity). The inspiratory action of the smooth muscles in distal parts of the lungs is a functional component along with surfactant that provides the consistency of alveoli during expirations (the third component).
About the Authors
Fedor F. Tetenev
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Academician of Russian Academy of Natural Science, Head of Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Russian Federation
Doctor of Medicine, Professor, Academician of Russian Academy of Natural Science, Head of Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Konstantin F. Tetenev
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Candidate of Medicine, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Russian Federation
Candidate of Medicine, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Tat'yana S. Ageeva
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 53-07-27;
Russian Federation
Doctor of Medicine, Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 53-07-27;
Tamara N. Bodrova
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Academician of Russian Academy of Natural Science, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Russian Federation
Doctor of Medicine, Professor, Academician of Russian Academy of Natural Science, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Aleksandr I. Karzilov
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Natural Science, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Russian Federation
Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Natural Science, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Pavel E. Mes’ko
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Candidate of Medicine, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Russian Federation
Candidate of Medicine, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Anna V. Teteneva
Siberian State Medical University, Healthcare Ministry of Russia
Russian Federation
Doctor of Medicine, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
Russian Federation
Doctor of Medicine, Associate Professor, Department of Propaedeutics of Internal Diseases, Siberian State Medical University, Healthcare Ministry of Russia; tel.: (3822) 90-11-01;
References
1. Carlson A., Luckhardt A. Studies on the visceral sensory nervous system. The action of certain drugs on the lungmotor mechanismus of the reptilian. Am. J. Physiol. 1921; 55: 13.
2. Kuhn T. The Structure of Scientific Revolutions. Translated from English. Moscow; 1975 (in Russian).
3. Donders F. Beitrage zum Mechanismus der Respiration und Circulation im gesunden und kranken Zustande. Ztschr. F. Rat. Med. 1853; (3): 287.
4. Orsos F. Uber die elastischen Geruste der normalen und der Emphysem lunge. Beitr Z. Path. Anatom.1907; 41: 95.
5. Orsos F. Die Gerustsysteme der Lunge und deren physiologischc und pathologische Bedeutung. Beitr. Zur. Klinik Fbc. 1936; 87: 586.
6. Makarov I.V. Bronchial breathing-related change in children using radiological methods with contrast enhancement. Voprosy okhrany materinstva i detstva. 1967; 12 (8): 87–88 (in Russian).
7. Gonzalez-Bogen A. The new theory of respiratory dynamics. Caracas: Ediciones de la biblioteca; 1985.
8. Belov E.I. About relations between intrathoracic pressure fluctuations and smooth muscle tone in the lungs. Fiziologicheskiy zhurnal SSSR. 1959; 45 (11): 1384–1387 (in Russian).
9. Mikhaylov F.A. About functions of the neuromuscular system of the lungs. Klinicheskaya meditsina. 1949; (5): 3–8 (in Russian).
10. Mikhaylov F.A. About reflectory reactions of the lungs in artificial pneumothorax. Klinicheskaya meditsina. 1951; 29 (6): 21–26 (in Russian).
11. Mikhaylov F.A. and Antonov Yu.V. About contractility of the lungs and its role for breathing. Klinicheskaya meditsina. 1952; (8): 18–21 (in Russian).
12. Khomyakov Yu.S. About the active contractility of the lungs. Sovetskaya meditsina. 1957; (6): 79–84 (in Russian).
13. Bucher R., Lang V. Anderungen des Lungenvolumes durch Pneumothorax. Schwez. Ztschr. f Fuberk. 1954; 11 (2): 146–152.
14. Mikhaylov D.M. The active tone of the lungs, breathing, respiratory mechanics and surface-active events in emphysema and atelectasis (an experimental study). Izhevsk; 1972 (in Russian).
15. Reinhardt E. Beitrage zur kenntnis der Lunge als neurovascularen und neuromuskularen Organs. Virchows Archiv. 1934; 292: 322–355.
16. Neergaard K., Wirz K. Uber eine Methode zur Messung der Lungelastizitat am Lebenden Menschen, insbesendere beim Emphysem. Ztschr. Klin. Med. 1927; 105: 35–50.
17. Neergaard K., Wirz K. Die Messung der Stromungesiderstande in den Atemwegen des Menschen insbesondere bei Asthma und Emphysem. Ztschr. Klin. Med. 1927; 105: 51–82.
18. Buytendijk H. Oesophagusdruck on Longelasticiteit. Groninger; 1949.
19. Mcllroy M., Marshall R., Christic A. The work of breathing in normal subjects. Clin. Sci. 1954; 13: 127–136.
20. Mcllroy M., Marshall R. The mechanical properties of the lung in asthma. Clin. Sci. 1954; 13: 137–146.
21. Mcllroy M., Christie R. The work of breathing in emphysema. Clin. Sci. 1954; 13: 147–154.
22. Marshall R., Christie R. The visco-clastic properties of the lungs in acute pneumonia. Clin. Sci. 1954; 13: 403–408.
23. Brown C., Fry D., Ebert R. The mechanism of pulmonary ventilation in patient with heart disease. Am. J. Med. 1954; 17: 438–446.
24. Wohl M., Furner J., Mead J. Static volume-pressure curves of dog lungin vivo and vitro. J. Appl. Physiol. 1968; 24 (3):348–354.
25. Macklem P., Murphy B., Eng B. The Forces Applied to lung in Health and Disease. Am. J. Med. 1974; 57 (10): 371–377.
26. Webb W., Smith J., Campbell Y. Peri-alveolar Pressure. Ann. Surg. 1961; 153 (5): 650–657.
27. Peress L., Sybrecht Y., Marklem P. The Mechanism of increase in Total lung Capacity During Acute Asthma. Am. J. Med. 1976; 61 (8): 165–169.
28. Machlem P. Respiratory mechanics. Annu. Rev. Physiol. 1978; 40: 157–184.
29. Nagaishi C., Ocada G. The structure of the bronchoalveolar System with special reference to its fine structure. Acta Tubercul. Jap.1960; 10 (1): 20–38.
30. Stead W., Fry D., Ebert R. The elastic properties of the lung in normal men and in patients with emphysema. J. Lab. Clin. Med. 1952; 40: 674–681.
31. Tetenev F.F. Work of breathing in patients with emphysema. Terapevticheskiy arkhiv. 1968; (11): 29–35 (in Russian).
32. Tetenev F.F. Elastic lung hysteresis in health and in disease. Byulleten' eksperimental'noy biologii. 1974; 77 (6): 21–23 (in Russian).
33. Tetenev F.F. Respiratory Biomechanics. Tomsk: Izdatel'stvovo Tomskogo univesiteta; 1981 (in Russian).
34. Tetenev F.F., Tetenev K.F. A theory of mechanic activity of the lungs: development, state of art and future perspectives. Uspekhi fiziologicheskikh nauk. 2014; 45 (2): 77–95 (in Russian).
35. Tetenev K.F., Tetenev F.F., Ageeva T.S. et al. Antagonistic mechanisms of valve obstruction of the bronchi in obstructive emphysema. Byulleten' sibirskoy meditsiny. 2015; 14 (4): 75–81 (in Russian).
36. Tetenev F.F., Tetenev K.F., Ageeva T.S. et al. Integral work of intrapulmonary source of mechanic energy in healthy subjects and in patients with obstructive lung diseases. Pul'monologiya. 2015; 25 (5): 586–592. DOI: 10.18093/0869-0189-2015-25-5-586-592 (in Russian).
37. Neergaard K. Neue Auffasungen uber einen Grundbegrift der Atemmchanik. Die Retraktionskraft der Lunge, abhangig von der Oberflachenspannung in den Alveolen. Ztschr. Ges. Exper. Med. 1929; 66: 373–394.
38. Pattle R. Surface lining of lung alveoli. Physiol. Rev. 1965; 45 (1): 48–79.
Review
For citations:
Tetenev F.F., Tetenev K.F., Ageeva T.S., Bodrova T.N., Karzilov A.I., Mes’ko P.E., Teteneva A.V. Three-component model of pulmonary mechanical activity. PULMONOLOGIYA. 2017;27(3):398-403. (In Russ.) https://doi.org/10.18093/0869-0189-2017-27-3-398-403
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