RARE COMPLICATIONS OF THERAPY OF CYSTIC FIBROSIS: CLOSTRIDIUM DIFFICILE-ASSOCIATED COLITIS
https://doi.org/10.18093/0869-0189-2016-26-5-556-559
Abstract
The aim of this study was to determine a rate of Clostridium difficileassociated colitis in patients with cystic fibrosis (CF). Methods. Qualitative and quantitative bacteriological examination with identification of C. difficile toxins A and B production was done in 61 intestinal contents samples from CF patients who previously received antibiotics. Results. Various disorders of qualitative and quantitative composition of the intestinal microflora were found in 100% of patients. Testing for C. difficile toxins A and B production was positive in 5 (15.2%) of patients. Conclusion. These patients could have a high risk of pseudomembranous colitis development.
About the Authors
O. V. Kondratenko
Samara State Medical University, Healthcare Ministry of Russia: 89, Chapaevskaya str., Samara, 443099, Russia
Russian Federation
PhD, Associate Professor at Department of General and Clinical Microbiology, Immunology and Allergology
Russian Federation
PhD, Associate Professor at Department of General and Clinical Microbiology, Immunology and Allergology
A. V. Lyamin
Samara State Medical University, Healthcare Ministry of Russia: 89, Chapaevskaya str., Samara, 443099, Russia
Russian Federation
PhD, Associate Professor at Department of General and Clinical Microbiology, Immunology and Allergology
Russian Federation
PhD, Associate Professor at Department of General and Clinical Microbiology, Immunology and Allergology
E. A. Vasil'eva
Samara Regional Center on Cystic Fibrosis at N.I.Ivanova' Samara State Pediatric Clinical Hospital No.1: 165a, Karla Marksa str., Samara, 443079, Russia
Russian Federation
Head of Samara Regional Center on Cystic Fibrosis
Russian Federation
Head of Samara Regional Center on Cystic Fibrosis
E. A. Zheleznova
Samara State Medical University, Healthcare Ministry of Russia: 89, Chapaevskaya str., Samara, 443099, Russia
Russian Federation
PhD, Associate Professor at Department of General and Clinical Microbiology, Immunology and Allergology
Russian Federation
PhD, Associate Professor at Department of General and Clinical Microbiology, Immunology and Allergology
References
1. Lobzin Yu.V., Zakharenko S.M., Ivanov G.A. Current approach to Clostridium difficile identification. Klinicheskaya mikrobiologiya i antimikrobnaya khimioter$ apiya. 2002; 4 (3): 200–232 (in Russian).
2. Gerding D.N., Johnson S., Peterson L.R. et al. Clostridium difficile associated diarrhea and colitis. Infect. Control Hosp. Epidemiol. 1995; 16: 459–477.
3. Shupel'kova Yu.O. Antibiotic associated dyarrhea. Russkiy meditsinskiy zhurnal. 2007; 15 (6): 1–6 (in Russian).
4. Fekety R., Shsh A.B. Diagnosis and treatment of Clostridium difficile colitis. JAMA. 1993, 209: 71–75.
5. Samore M.H., DeGirolami P.C., Tlucko A. et al. Clost ridium difficile colonization and diarrhea at a tertiary care hospital. Clin. Infect. Dis. 1994; 18: 181–187.
6. Zaplatnikova A.L., Zakharova I.N., Korovina N.A. Clostridium difficile infection in children. Russkiy meditsin$ skiy zhurnal. 2004; 12 (5): 373–376 (in Russian).
7. Clostridium difficile. In: Pickering L.K., ed. 2000 Red Book. Report of the Committee on Infection Diseases. 25th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2000: 2014–2016.
8. Rolfe R.D., Song W. Immunoglobulin and non immu noglobulin components of human milk inhibit Clostridium difficile toxin A receptor binding. J. Med. Microbiol. 1995; 42: 10–19.
9. Dallas S.D., Rolfe R.D. Binding of Clostridium Difficile toxin A to human milk secretory component. J. Med. Microbiol. 1998, 47: 879–888.
10. Kapranov N.I., Kashirskaya N.Yu., eds. Cystic Fibrosis. Moscow: Medpraktika M; 2014 (in Russian).
11. Dysbiosis of Gut Microbiota. A Protocol for Patient Management. Branch Standard No.91500.11.0004 2003. Healthcare Ministry of Russian Federation, 2003 (in Russian).
12. Labinskaya A.S., Kostyukova N.N., eds. Handbook on Medical Misrobiology. Opportunistic Infections: Pathogens and Etiological Diagnosis. Book 3.1. Moscow: Binom; 2013: 454–473 (in Russian).
13. Labinskaya A.S., Kostyukova N.N., eds. Handbook on Medical Misrobiology. Opportunistic Infections: Pathogens and Etiological Diagnosis. Book 3.2. Moscow: Binom; 2014: 284–288 (in Russian).
Review
For citations:
Kondratenko O.V., Lyamin A.V., Vasil'eva E.A., Zheleznova E.A. RARE COMPLICATIONS OF THERAPY OF CYSTIC FIBROSIS: CLOSTRIDIUM DIFFICILE-ASSOCIATED COLITIS. PULMONOLOGIYA. 2016;26(5):556-559. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-5-556-559
Views:
820
Email this article 