Lung injury as a complication of treatment with amiodarone
https://doi.org/10.18093/0869-0189-2016-26-2-246-253
Abstract
This is a review of current literature on lung injury which is one of the most hazardous adverse effects of an antiarrhythmic agent amiodarone referred to as amiodarone-induced pulmonary toxicity (AIPT). Finding on AIPT prevalence, risk factors, dose dependence, therapy duration and probability of AIPT occurrence have been analyzed. Issues of clinical pharmacology and the most common adverse effects of amiodarone have been discussed. Pathophysiological and pathological features and clinical manifestations of AIPT including diffuse pneumonitis, bronchiolitis, respiratory failure and acute respiratory distress syndrome have been described. Diagnosis of AIPT is based on routine methods such as lung function tests, chest X-ray, high-resolution computed tomography, and lung tissue biopsy. Management approaches include dose reduction or drug withdrawal and administration of systemic steroids. Preventive measures include baseline spirometry, regular X-ray examination and information about symptoms of this complication provided to the patients.
About the Authors
N. T. Vatutin
M.Gor'kiy Donetsk National Medical University: 16, Il'icha av., Donetsk, 83005, Ukraine;
V.K.Gusak' State Institute of Emergent and Reconstructive Surgery, National Academy of Medical Science: 47, Leninskiy av., Donetsk, 83000, Ukrainе
Ukraine
Ukraine
MD, Professor, Head of Department of Hospital Internal Medicine, M.Gor'kiy Donetsk National Medical University; tel.: +38062-385-05-17;
G. G. Taradin
M.Gor'kiy Donetsk National Medical University: 16, Il'icha av., Donetsk, 83005, Ukraine;
Ukraine
Ukraine
PhD, Associate Professor at Department of Hospital Internal Medicine, M.Gor'kiy Donetsk National Medical University; tel.: +38050-055-08-05;
Yu. P. Gritsenko
M.Gor'kiy Donetsk National Medical University: 16, Il'icha av., Donetsk, 83005, Ukraine;
Ukraine
Ukraine
the 4th year student of Medical Faculty, M.Gor'kiy Donetsk National Medical University; tel.: +38062-385-05-17;
References
1. Williams E.M.V. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J. Clin. Pharmacol. 1984; 17: 129–147.
2. Roy D., Talajic M., Dorian P. et al. Amiodarone to prevent recurrence of atrial fibrillation. Canadian trial of atrial fibrillation investigators. N. Eng. J. Med. 2000; 342: 913–20.
3. Mazur N.A. Practical Cardiology. Moscow: Medpraktika; 2012 (in Russian).
4. Ernawati D.F., Stafford L., Hughes F.D. Amiodarone-induced pulmonary toxicity. Br. J. Clin. Pharmacol. 2008; 66: 82–87.
5. Jarand J., Lee A., Leigh R. Amiodaroma: an unusual form of amiodarone-induced pulmonary toxicity. CMAJ. 2007; 176: 1411–1413.
6. Range F.T. Amiodarone-induced pulmonary toxicity – a fatal case report and literature review. Cardiovasc. Drugs. 2013; 27 (3): 247–254. DOI: 10.1007/s10557-013-6446-0.
7. Wolkove N., Baltzan M. Amiodarone pulmonary toxicity. Can. Respir. J. 2009; 16:43–48.
8. Dharmarajan T.S., Shah A.B., Dharmarajan L. Amiodarone-induced pulmonary toxicity: potentially fatal, recognize early during life! J. Am. Geriatr. Soc. 2008; 56: 1363–1365.
9. Papiris S.A., Triantafillidou C., Kolilekas L. et al. Amiodarone: review of pulmonary effects and toxicity. Drug Saf. 2010; 33: 539–558.
10. Goldschlager N., Epstein A.E., Naccarelli G.V. et al. A practical guide for clinicians who treat patients with amiodarone. Heart Rhythm. 2007; 4: 1250–1259.
11. Camus P., Martin W.J. II, Rosenow E.C. III. Amiodarone pulmonary toxicity. Clin. Chest Med. 2004; 25: 65–75.
12. Sunderj R., Kanji Z., Gin K. Pulmonary effects of low dose amiodarone: a review of the risks and recommendations for surveillance. Can. J. Cardiol. 2000; 16: 1435–1440.
13. Ott M.C., Khoor A., Leventhal J.P. et al. Pulmonary toxicity in patients receiving low-dose amiodarone. Chest. 2006; 123: 646–651.
14. Fabiani I., Tacconi D., Grotti S. et al. Amiodarone-induced pulmonary toxicity mimicking acute pulmonary edema. J. Cardiovasc Med. (Hagerstown). 2011; 12: 361–365.
15. Ashrafian H., Davey P. Is amiodarone an underrecognized cause of acute respiratory failure in the ICU? Chest. 2001; 120: 275–282.
16. Saussine M., Colson P., Alauzen M., Mary H. Postoperative acute respiratory distress syndrome: a complication of amiodarone associated with 100 percent oxygen ventilation. Chest. 1992; 102: 980–981.
17. Greenspon A.J., Kidwell G.A., Hurley W., Mannion J. Amiodarone-related postoperative adult respiratory distress syndrome. Circulation. 1991; 84: 407–415.
18. Siddoway L. Amiodarone: guidelines for use and monitoring. Am. Fam. Physician. 2003; 68: 2189–2196.
19. Vassallo P., Trohman R.G. Prescribing amiodarone: an evidence-based review of clinical indications. JAMA. 2007; 298: 1312–1322.
20. Zimetbaum P. Amiodarone for atrial fibrillation. N. Eng. J. Med. 2007; 356: 935–941.
21. Schwaiblmair M., Berghaus T., Haeckel T. et al. Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect? Clinical research in cardiology. Germ. Card. Soc. 2010; 99: 693–700.
22. Malhotra A., Muse V.V., Mark E.J. An 82 year old man with dyspnea and pulmonary abnormalities. Case records of the Massachusetts General Hospital. N. Eng. J. Med. 2003; 348: 1574–1585.
23. Viswam D., Nair S.G., Patel V., Nagaraj. Ultra-short course of low-dose amiodarone-induced post-operative fatal pulmonary toxicity. J. Assoc. Physicians. India. 2011; 59: 443–447.
24. Iskandar S.B., Abi-Saleh B., Keith R.L. et al. Amiodarone-induced alveolar hemorrhage. South Med. J. 2006; 99: 329–330.
25. Handschin A.E., Lardinois D., Schneiter D. et al. Acute amiodarone-induced pulmonary toxicity following lung resection. Respiration. 2003; 70: 310–312.
26. Lee W., Ryu D.R., Han S.S. et al. Very early onset of amiodarone-induced pulmonary toxicity. Korean. Circ. J. 2013; 43: 699–701. DOI: org/10.4070/kcj.2013.43.10.699.
27. Feshchenko Yu.I., Rekalova E.M., Begouleva Zh.B. et al. Two case reports of amiodarone-induced pulmonary toxicity. Ukraїns'kiy pul'monologichniy zhurnal. 2004; 4: 55–58 (in Ukranian).
28. Nacca N.J., Bhamidipati C.M., Yuhico L.S. et al. Severe amiodarone induced pulmonary toxicity. Thorac. Dis. 2012; 4 (6): 667–670. DOI: 10.3978/j.issn.2072-1439.2012.06.08.
29. Van Mieghem W., Coolen L., Malysse I. et al. Amiodarone and the development of ARDS after lung surgery. Chest. 1994; 105: 1642–1645.
30. Chuang C.L., Chern M.S., Chang S.C. Amiodarone toxicity in a patient with simultaneous involvement of cornea, thyroid gland, and lung. Am. J. Мed. Sci. 2000; 320: 64–68.
31. Endoh Y., Hanai R., Uto K. et al. Diagnostic usefulness of KL-6 measurements in patients with pulmonary complications after administration of amiodarone. J Cardiol. 2000; 35: 121–127.
32. Azzam I., Tov N., Elias N., Naschitz J.E. Amiodarone toxicity presenting as a pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge. Postgrad. Med. J. 2006; 82: 73–75.
33. Tanawuttiwat T., Harindhanavudhi T., Hanif S., Sahloul M.Z. Amiodarone-induced alveolar haemorrhage: a rare complication of a common medication. Heart Lung Circ. 2010; 19 (7): 435–437. DOI: 10.1016/j.hlc.2010.01.008.
34. Aasbo J.D., Lawrence A.T., Krishnan K. et al. Amiodarone prophylaxis reduces major cardiovascular morbidity and length of stay after cardiac surgery: a meta-analysis. Ann. Intern. Med. 2005; 143: 327–336.
35. Barlamov P.N., Mokrushina Yu.S., Shchekotov V.V. Amiodarone-induces pneumopathy. Klinicheskaya meditsina. 2013; 91 (8): 64–66 (in Russian).
36. Okayasu K., Takeda Y., Kojima J. et al. Amiodarone pulmonary toxicity: a patient with three recurrences of pulmonary toxicity and consideration of the probable risk of relapse. Intern. Med. 2006; 45: 1303–1307.
37. Benassi F., Molardi A., Righi E. et al. ECMO for pulmonary rescue in an adult with amiodarone-induced toxicity. Heart Vessels. 2015; 30 (3): 410–415. DOI: 10.1007/s00380-014-0487-6.
38. Mankikian J., Favelle O., Guillon A. et al. Initial characteristics and outcome of hospitalized patients with amiodarone pulmonary toxicity. Respir. Med. 2014; 108 (4): 638–646.
39. Card J.W., Racz W.J., Brien J.F., Massey T.E. Attenuation of amiodarone induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction. J. Pharmacol. Exp. Ther. 2003; 304: 277–283.
Review
For citations:
Vatutin N.T., Taradin G.G., Gritsenko Yu.P. Lung injury as a complication of treatment with amiodarone. PULMONOLOGIYA. 2016;26(2):246-253. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-2-246-253
Views:
6649
Email this article 