Symptoms and quality of life in patients with chronic obstructive pulmonary disease: are there patient_defined outcomes or predictive factors?
https://doi.org/10.18093/0869-0189-2016-26-2-231-237
Abstract
Novel medications for therapy of chronic obstructive pulmonary disease (COPD), primarily long-acting bronchodilators, could reduce severity of symptoms.
Nevertheless, 50% to 70% of patients continue to experience significant dyspnea despite the therapy. Early diagnosis of COPD is a quite difficult clinical problem, whereas an active treatment is usually required at early-stage disease because of decreasing physical tolerance and, importantly, rapidly declining pulmonary function. Novel fixed combinations of long-acting beta-2-agonists (LABA) and long-acting muscarinic antagonists (LAMA) deliver both the drugs in a single inhaler. These combinations have been shown to be more effective compared to monotherapy with the components. One of new LABA/LAMA combinations is tiotropium/olodaterol combination (Spiolto Respimat). Several large clinical trials (TONADO 1 and 2, ОTEMTO 1 and 2) demonstrated significant improvement in quality of life and dyspnea in patients with COPD taking the tiotropium/olodaterol combination. This combined drug was highly effective in early-stage COPD.
About the Author
S. N. Avdeev
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia
Russian Federation
Russian Federation
MD, Professor, Head of Clinical Division, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; tel. / fax: (495) 465-52-64;
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For citations:
Avdeev S.N. Symptoms and quality of life in patients with chronic obstructive pulmonary disease: are there patient_defined outcomes or predictive factors? PULMONOLOGIYA. 2016;26(2):231-237. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-2-231-237
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