Preview

PULMONOLOGIYA

Advanced search

Mobile cardiorespiratory and metabolic laboratory: diagnosis of chronic obstructive pulmonary disease, cardiovascular and metabolic diseases

https://doi.org/10.18093/0869-0189-2016-26-2-215-221

Abstract

The aim of this study was to determine risk factors of chronic non-infectious diseases and early diagnosis of cardiovascular, respiratory and endocrine functional disorders in industrial workers using a mobile cardiorespiratory and metabolic laboratory. Methods. This was a prospective non-comparative observational study in a non-selected population. All participants underwent the following measurements: weight and height, wrist and thigh circumferences, pulse oxymetry, exhaled nitric oxide (NO) and exhaled carbon monooxide (CO), spirometry before and after bronchodilator inhalation, electrocardiogram, arterial stiffness and endothelial dysfunction, blood glucose and blood total cholesterol. Indirect calorimetry with energy expenditure calculation was used in several patients. Validated questionnaires were also used. Results. The study involved 194 industrial workers. High prevalence of risk factors, such as tobacco smoking (45% of active smokers, 31% of ex-smokers), obesity (BMI ≥ 30 kg x m–2 in 37%), hypercholesterolemia (34%), and endothelial dysfunction (57%), was found. Vascular biomechanics correlated with bronchial patency, systemic arterial pressure and exhaled CO concentration. Bronchial obstruction was found in 56% of subjects, of them, COPD was diagnosed in 13%. Conclusion. Mobile cardiorespiratory and metabolic laboratory allows medical care delivery directly to a working place, and effective detection of risk factors and chronic lung disease.

About the Authors

S. Z. Batyn
Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

PhD, Senior Researcher at Laboratory of Intensive Care and Respiratory Failure, Head of Organisational and Methodological Group, Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 465-52-64;



A. V. Chernyak
Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

PhD, Head of Laboratory of Functional and Ultra-sound Investigations; Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 465-53-84;



G. V. Neklyudova
Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

MD, Chief Scientist at Laboratory of Functional and Ultra-sound Investigations; Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 465-53-84;



Zh. K. Naumenko
Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

PhD, Senior Researcher at Laboratory of Functional and Ultrasound Investigations, Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 465 53 84;  



E. A. Ermakova
State Institution «Russian Medical Postgraduate Academy», Healthcare Ministry of Russia: 2/1 Barrikadnaya str., Moscow, 123995, Russia;
Russian Federation

PhD student at Department of Endocrinology and Diabetology, State Institution «Russian Medical Postgraduate Academy», Healthcare Ministry of Russia; tel.: (499) 252-21-04



V. A. Shtabnitskiy
State Institution «N.I.Pirogov Russian National Research Medical University», Healthcare Ministry of Russia: 1 Ostrovityanova str., Moscow, 117997, Russia
Russian Federation

PhD, Assistant Lecturer at Department of Hospital Internal Medicine, Pediatric Faculty, State Institution «N.I.Pirogov Russian National Research Medical University», Healthcare Ministry of Russia; Junior Researcher at the Laboratory of Clinical Pharmacology, Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 465-52-64;



Z. R. Aysanov
Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

MD, Professor, Head of Division of Clinical Physiology and Clinical Trials, Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia; tel.: (495) 465-53-84;



A. G. Chuchalin
Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia;
Russian Federation

MD, Professor, Academician of Russian Science Academy, Director of Federal Institution «Pulmonology Research Institute», Federal Medical and Biological Agency of Russia;



References

1. HYPERLINK "http://www.WHO.int/ru/" http://www.WHO.int/ru/

2. Boytsov S.A., Chuchalin A.G., eds. Prevention of chronic non-infectious diseases. Methodological guidelines. Moscow; 2013. Available at: HYPERLINK "http://www.ropniz.ru" http://www.ropniz.ru (in Russian).

3. Anthonisen N., Skeans M., Wise R. et al. The effects of a smoking cessation intervention on 14.5-year mortality: A randomized clinical trial. Ann. Intern. Med. 2005; 142: 233–239.

4. Pelkonen M., Notkola I., Tukiainen H. et al. Smoking cessation, decline in pulmonary function and total mortality: A 30 year follow up study among the Finnish cohorts of the seven countries study. Thorax. 2001; 56: 703–707.

5. Millasseau S.C., Guigui F.G., Kelly R.P. et al. Noninvasive assessment of the digital volume pulse. Comparison with the peripheral pressure pulse. Hypertension. 2000; 36: 952–956.

6. Bramwell J.C., Hill A.V. The velocity of the pulse wave in man. Proceedings of the Royal Society. London: Ser B. 1922; 93: 298–306.

7. Korteweg D.J. Über die Fortpflanzungsgesschwindigkeit des Schalles in elastischen Rohren. Ann. Phys. Chem. (NS). 1878; 5: 520–537.

8. O’Rourke M.F., Staessen J.A., Vlachopoulos C. et al. Clinical applications of arterial stiffness; Definitions and reference values. Am. J. Hypert. 2002; 5; 426–444.

9. Makarova M.A. Arterial stiffness and endothelial dysfunction in patients with chronic obstructive pulmonary disease: Diss. Moscow; 2011 (in Russian).

10. Tsyplenkova S.E., Mizernitskiy Yu.L. Clinical significance of exhaled nitric oxide measurement in children with respiratory diseases. Moscow: Media Sfera; 2005 (in Russian).

11. Jones S.L., Kittelson J., Cowan J.O. The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am. J. Respir. Crit. Care Med. 2001; 164: 738–743.

12. www.goldcopd.org/uploads/users/files/GOLD_Report_2014_Jan23.pdf


Review

For citations:


Batyn S.Z., Chernyak A.V., Neklyudova G.V., Naumenko Zh.K., Ermakova E.A., Shtabnitskiy V.A., Aysanov Z.R., Chuchalin A.G. Mobile cardiorespiratory and metabolic laboratory: diagnosis of chronic obstructive pulmonary disease, cardiovascular and metabolic diseases. PULMONOLOGIYA. 2016;26(2):215-221. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-2-215-221

Views: 830


ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)