Glomerular filtration rate in bronchial asthma: effects of adipokines
https://doi.org/10.18093/0869-0189-2016-26-2-196-200
Abstract
The aim of the study was to analyze a relationship between key adipokines expression and the glomerular filtration rate (GFR) in different clinical variants of bronchial asthma (BA). Methods.We examined 178 patients with different clinical variants of BA. The glomerular filtration rate (eGFR) was estimated using CKD-EPI. Plasma concentrations of leptin, adiponectin, resistin, and apelin were measured using the ELISA method. Correlation and factor analyses were performed using the SPSS program for Windows, version 13.0. Results. A relationship between eGFR, key adipokines expression and pSTAT3 transcription factor expression, which is involved in proinflammatory adipokines effect transduction in BA, was found. Moreover, a reverse relationship between eGFR and adipokines (leptin, resistin, adiponectin) expression was mainly typical for allergic BA. Conclusion. Additional risk factors for development and progress of chronic renal disease are probably present in patients with BA even without obesity.
About the Authors
V. N. Mineev
Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia: 6 – 8, L'va Tolstogo str., Saint-Petersburg, 197022, Russia;
Russian Federation
Russian Federation
MD, Professor at M.V.Chernorutskiy Department of Hospital Internal Medicine, Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia; tel.: (812) 450-71-63;
T. S. Vasil'eva
City State Outpatient Clinic No.34: 15, Zverinskaya str., Saint-Petersburg, 197198, Russia
Russian Federation
Russian Federation
PhD, General Practitioner at City State Outpatient Clinic No.34; tel.: (950) 030-41-13;
T. M. Lalaeva
Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia: 6 – 8, L'va Tolstogo str., Saint-Petersburg, 197022, Russia;
Russian Federation
Russian Federation
MD, Assistant Lecturer at M.V.Chernorutskiy Department of Hospital Internal Medicine, Academician I.P.Pavlov First Saint-Petersburg State Medical University, Healthcare Ministry of Russia; tel.: (911) 912-89-43;
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For citations:
Mineev V.N., Vasil'eva T.S., Lalaeva T.M. Glomerular filtration rate in bronchial asthma: effects of adipokines. PULMONOLOGIYA. 2016;26(2):196-200. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-2-196-200
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