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Extrinsic interstitial lung disease activity markers

https://doi.org/10.18093/0869-0189-2016-26-2-180-185

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Abstract

The aim of this study was to investigate values of pulmonary fibrosis markers alveomucin and KL-16 and the airway damage marker CC-16 for evaluating activity and progressing of extrinsic interstitial lung diseases (ILD) in dependence on etiology. Methods. Levels of Krebs von den Lungen-6 glycoprotein (KL-6), alveomucin and Clara cell protein (CC16) were measured using the ELISA method. The study involved 13 patients with pneumoconiosis, 26 patients with extrinsic allergic alveolitis (EAA) and 20 patients with extrinsic toxic alveolitis (ETA) both in active and stable status. Results. KL-6 and alveomucin were found to be more valuable markers for assessing activity of extrinsic fibrosing alveolitis compared to CC16. Alveomucin had higher specificity but lower sensitivity compared to KL-6. Conclusion. Alveomucin could be used as a screening test in cases with clinical susceptibility for extrinsic alveolitis. On contrary, KL-6 and alveomucin could be used for assessing therapeutic efficacy of EAA and ETA.

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Orlova G.P., Surkova E.A., Lapin S.V. Extrinsic interstitial lung disease activity markers. PULMONOLOGIYA. 2016;26(2):180-185. (In Russ.) https://doi.org/10.18093/0869-0189-2016-26-2-180-185

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)