Granulomatosis with polyangiitis manifested with asthma-like syndrome followed by pneumonia6like syndrome
https://doi.org/10.18093/0869-0189-2015-25-6-753-756
Abstract
A case of granulomatosis with polyangiitis is described in the article. The patient experienced 3year paroxysmal asthmalike syndrome with granulomatous lesion of the subglottic portion of the larynx that further developed into multifocal destructive lesions of the lungs without clinical signs of glomerulonephritis and with positive response to combined therapy with cytostatic agents, rituximab and systemic steroids. The main criteria of granulomatosis with polyangiitis in this patient were high levels of ANCA and antiproteinase3 antibodies. Therefore, granulomatosis with polyangiitis is characterized by polymorphic onset of lung disease with coexisting paroxysmal respiratory syndrome, infiltrative and destructive pulmonary lesions.
About the Authors
A. Yu. Tret'yakov
Federal Belgorod National Research University: 85, Pobedy str., Belgorod, 308015, Russia
Russian Federation
Russian Federation
MD, Professor, Federal Belgorod National Research University, Belgorod, Russia; tel.: (4722) 301379
S. P. Zakharchenko
Federal Belgorod National Research University: 85, Pobedy str., Belgorod, 308015, Russia
Russian Federation
Russian Federation
PhD, Senior Researcher at Federal Belgorod National Research University; tel.: (4722) 301379
V. N. Shilenok
Medical Diagnostic Center “Tomograph”: 4, Druzhby str., Kursk, 305018, Russia
Russian Federation
Russian Federation
PhD, Deputy Chief Medical Officer at Medical Diagnostic Center “Tomograph”; tel.: (4712) 732000
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Review
For citations:
Tret'yakov A.Yu., Zakharchenko S.P., Shilenok V.N. Granulomatosis with polyangiitis manifested with asthma-like syndrome followed by pneumonia6like syndrome. PULMONOLOGIYA. 2015;25(6):753-756. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-6-753-756
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