Innovative drugs at the 21th century

Abstract

Currently, new drugs have being developed with a conceptually new research design based on human genome findings. Mainly, new drugs are intend ed for treatment of chronic noninfectious diseases, primarily, cardiovascular diseases, malignancies and respiratory diseases. One of the fundamental research directions is searching for target molecules including lipid metabolism regulators, anticoagulants, fibrinolytics, and monoclonal antibodies. The former are considered as target therapy in cardiology, dermatology, oncology, rheumatology, allergology, pulmonology, ophthalmology, etc. Another important direction is development of orphan drugs. Further basic knowledge is needed for development of new drug generations.