Changes in bronchial mucosa in smokers with chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2015-25-3-357-362
Abstract
The aim of the study was to describe tissue, cellular and molecular particularities of the bronchial mucosa in smokers with chronic obstructive pulmonary disease (COPD). Methods. Morphological investigation of bronchial wall biopsy in smokers with and without COPD was made. Results. Bronchial wall structural disorders were seen in smokers without clinical manifestations of the disease which were considered as compensatory changes. Morphological features of hemodynamic abnormalities, perivascular fibrosis of the lamina propria, squamous cell metaplasia, atrophy of the bronchial epithelium associated with endothelial dysfunction and dysregeneration of the epithelial cells were found in smokers with clinically significant COPD. Conclusion. Morphological changes in bronchial wall are thought to be related to COPD severity.
About the Authors
E. A. Gereng
State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; 2, Moskovskiy trakt, Tomsk, 634050, Russia
Russian Federation
Russian Federation
MD, Professor at the Department of Morphology and General Pathology, Senior Researcher at the Central Research Laboratory, State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; tel.: (382) 242-64-43;
I. V. Sukhodolo
State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; 2, Moskovskiy trakt, Tomsk, 634050, Russia
Russian Federation
Russian Federation
MD, Professor, Head Department of Morphology and General Pathology, State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; tel.: (382) 242-64-43;
R. I. Pleshko
State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; 2, Moskovskiy trakt, Tomsk, 634050, Russia
Russian Federation
Russian Federation
MD, Professor at the Department of Morphology and General Pathology, State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; tel.: (382) 242-64-43;
E. B. Bukreeva
State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; 2, Moskovskiy trakt, Tomsk, 634050, Russia
Russian Federation
Russian Federation
MD, Professor at the Department of Internal Medicine, Pediatric Faculty, State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; tel.: (382) 241-98-44;
I. A. Kremis
State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; 2, Moskovskiy trakt, Tomsk, 634050, Russia
Russian Federation
Russian Federation
PhD student, Department of Internal Medicine, Pediatric Faculty, State Institution “Siberian State Medical University”, Healthcare Ministry of Russia; tel.: (382) 241-98-44;
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Review
For citations:
Gereng E.A., Sukhodolo I.V., Pleshko R.I., Bukreeva E.B., Kremis I.A. Changes in bronchial mucosa in smokers with chronic obstructive pulmonary disease. PULMONOLOGIYA. 2015;25(3):357-362. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-3-357-362
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