Значение фиксированных комбинаций длительно действующих антихолинергических препаратов и длительно действующих #b2-агонистов в терапии хронической обструктивной болезни легких
https://doi.org/10.18093/0869-0189-2015-25-1-93-100
Аннотация
Терапия фиксированными комбинациями длительно действующих антихолинергических препаратов (ДДАХП) и длительно действующих #b2-агонистов (ДДБА) на основе индакатерола и гликопиррония характеризуется высокой клинической эффективностью по сравнению с монокомпонентами препарата. По результатам проведенных клинических исследований подтверждена фармакологическая концепция о синергичном потенцировании бронхорасширяющего эффекта при использовании препаратов с разными механизмами действия, каковыми являются ДДБА и ДДАХП. Важно, что достижение дополнительного терапевтического эффекта возможно без повышения риска развития нежелательных явлений. Все это является основанием для заключения, что при совместном назначении индакатерола и гликопиррония оптимизируется и производит максимальный эффект бронходилатация у многих пациентов с хронической обструктивной болезнью легких (ХОБЛ), у которых не достигается адекватного улучшения бронхиальной проходимости при использовании лишь одного бронходилататора. При комбинированной терапии индакатеролом и гликопирронием (препарат QVA149) у пациентов c ХОБЛ значительно улучшаются клинические симптомы, легочная функция, качество жизни, снижается число обострений.
Об авторе
С. Н. Авдеев
ФГБУ «НИИ пульмонологии» ФМБА России: 105077, Москва, ул. 11-я Парковая, 32, корп. 4
Россия
Россия
д. м. н., проф., руководитель клинического отдела ФГБУ «НИИ пульмонологии» ФМБА России; тел. / факс: (495) 465-52-64;
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Рецензия
Для цитирования:
Авдеев С.Н. Значение фиксированных комбинаций длительно действующих антихолинергических препаратов и длительно действующих #b2-агонистов в терапии хронической обструктивной болезни легких. Пульмонология. 2015;25(1):93-100. https://doi.org/10.18093/0869-0189-2015-25-1-93-100
For citation:
Avdeev S.N. A role of fixed combinations of long-acting anticholinergics and long-acting #b2-agonists in therapy of chronic obstructive pulmonary disease. PULMONOLOGIYA. 2015;25(1):93-100. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-1-93-100
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