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Searching the truth: what is bronchial asthma?

https://doi.org/10.18093/0869-0189-2015-25-1-5-18

Abstract

Authors of this article have been studying clinical and pathogenic features of bronchial asthma for about 40 years. As a result, 10 clinicopathological variants of asthma have been described. This classification is based on a type of the airway inflammation, age at the disease onset, triggers and risk factors, presence of upper airway disease, endocrine and immune pathology, psychological characteristics of the patients, clinical features and course of asthma. An algorithm of diagnosis has been developed for each clinicopathological variant. Recently, according to a tendency to describe different asthma phenotypes the authors propose the term “clinicopathological phenotypes of asthma” in order to bring Russian terminology in line with international consensuses.

About the Authors

G. B. Fedoseev
State Institution "Academician I.P.Pavlov First Saint
Russian Federation

MD, Professor, Department of Hospital Internal Medicine, State Institution "Academician I.P.Pavlov First Saint



V. I. Trofimov
State Institution "Academician I.P.Pavlov First Saint
Russian Federation

MD, Professor, Head of Department of Hospital Internal Medicine, State Institution "Academician I.P.Pavlov First Saint



N. L. Shaporova
State Institution "Academician I.P.Pavlov First Saint
Russian Federation

MD, Professor, Head of Department of General Medical Practice (Family Medicine), State Institution "Academician I.P.Pavlov First Saint



V. A. Aleksandrin
State Institution "Academician I.P.Pavlov First Saint
Russian Federation

Associate Professor of the Department of Hospital Internal Medicine, State Institution "Academician I.P.Pavlov First Saint



N. A. Filippova
State Institution "Academician I.P.Pavlov First Saint
Russian Federation

PhD, Associate Professor of the Department of Hospital Internal Medicine, State Institution "Academician I.P.Pavlov First Saint



K. N. Kryakunov
State Institution "Academician I.P.Pavlov First Saint
Russian Federation

PhD, Assistant Professor, Associate Professor of the Department of Hospital Internal Medicine, State Institution "Academician I.P.Pavlov First Saint



References

1. Turner-Warwick. On observing patterns of airflow obstruction in asthma. Br. J. Dis. Chest. 1977, 71: 73–86.

2. Адо А.Д., Булатов П.К. Клинико-физиологические основы классификации бронхиальной астмы. В кн.: Материалы V Межбольничной научной конференции терапевтов «Этиология, патогенез, клиника и лечение заболеваний органов дыхания». Л.; 1969: 258–265.

3. Федосеев Г.Б. Современное представление о причинах возникновения, особенностях течения и лечения бронхиальной астмы. Актовая речь. Л.: «1ЛМИ им. акад. И.П.Павлова»; 1982.

4. Федосеев Г.Б., Хлопотова Г.П., Вишнякова Л.А. и др. Варианты течения и принципы профилактики и лечения бронхиальной астмы. Клиническая медицина. 1985; 7: 34–39.

5. Lai A.S.J., Schmeck B.T. Asthma phenotyping, Therapy, and prevention: what can we learn fro systems biology? Pediatric. Res. 2013; 73: 543–552.

6. Simpson J.L., Scott R., Boyle M.J., Gibson P.G. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology. 2006; 11: 54–61.

7. Green R.H., Brightling C.E., McKenna S. et al. Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet. 2002; 360: 1715–1721.

8. Wenzel S. Severe asthma: from characteristics to phenotypes to endotypes. Clin. Exp. Allergy. 2012, 42 (5): 650–658.

9. Ненашева Н.М. Современное представление о фенотипах бронхиальной астмы. Фарматека. 2013; 4: 41–46.

10. Everitt B.S., Landau S., Leese M. Cluster Analysis. London: Arnold; 2001.

11. Weatherall M., Shirtcliffe P., Travers J., Beasey R. Use of analysis to define COPD phenotypes. Eur. Resp. J. 2010; 36 (3): 472–474.

12. Just J., Gouvis-Echraghi R., Rouve S. et al. Two novel, severe asthma phenotypes indentified during childhood using a clustering approach. Eur. Resp. J. 2012; 40 (1); 55–60.

13. De Nijs S.B., Venekamp L.N., Bel E.H. Adult-onset asthma: is it really different? Eur. Resp. Rev. 2013; 22 (127): 44–52.

14. Ravindran C. Asthma phenotypes. Medicine. 2012; 22: 367–369.

15. Boudier A., Curjuris I., Basagana X. et al. Ten-year follow-up of cluster-based asthma phenotypes in adults. A pool analysis of three cohorts. Am. J. Respir. Crit. Care Med. 2013; 188 (5): 550–560.

16. Hancox R.J., Cowan D.C., Aldridge R.E. et al. Asthma phenotypes: Consistency of classification using induced sputum. Respirology. 2012; 17 (3): 461–466.

17. Aldridge R.E., Hencox R.L., Robin Taylor D. et al. Effects or terbutaline and budesonide on sputum cells and bronchial hyperresponsiveness in asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 1459–1464.

18. Simpson J.L., Scott R, Boyle M.J. et al. Inflammatory subtypes in asthma assessment and identification using induced sputum. Respirology. 2006: 11: 54–61.

19. Agache I., Akdis C. Untanging asthma phenotypes and endotypes. Allergy. 2012; 67 (7): 835–846.

20. Wenzel S. Severe asthma: from characteristics to phenotype to endotypes. Clin. Exp. Allergy. 2012; 42 (5): 650–658.

21. Wenzel S. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 2012; 18 (5): 716–725.

22. Anderson G.P. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008; 372: 1107–1119.

23. Wenzel S. Severe asthma: from characteristics to phenotypes. Clin. Immunol. 2014; 133 (5): 1474–1477.

24. Siroux V., Basagada X., Boudier A. et al. Identifying adult asthma phenotypes using a clustering approach. Eur. Resp. J. 2011: 38 (2): 310–317.

25. Bel E.N. Clinical phenotypes of asthma. Curr. Opin. Pulm. Med. 2004; 10 (1): 44–50.

26. Weatherall M., Travers J., Shietcliffe P.M. et al. Distinct clinical phenotypes of airways disease defined by cluster analysis. Eur. Respir. J. 2009; 34: 812–818.

27. Baines K.J., Simpson J.I., Wood L.G. et al. Transcriptional phenotypes of asthma defined by gene expression profiling of induced sputum samples. J. Allergy Clin. Immunol. 2011; 127 (1): 153–160.

28. Berry M., Morgan A., Shaw D. et al. Pathological features and inhaled corticosteroid response of eosinohilic and non-eosinophilic asthma. Thorax. 2007; 62 (12): 1043–1049.

29. McGrath K.W., Icitovic N., Boushey H.A. et al. A large subgroup of mid-to-moderate asthma is persistently noneosinophilic. Am. J. Respir. Crit. Care. Med. 2012; 185 (6): 612–619.

30. Leuppi J.D., Salome C.M., Jenkins C.R. et al. Markers of airway hyperresponsiveness in patients with well-controlled asthma. Eur. Respir. J. 2001; 18: 444–450.

31. Nair P. What is an «eosinophilic phenotype» of asthma? J. Allergy Clin. Immunol. 2013; 132 (1): 81–83.

32. Bartoli M.L., Bassi E., Carnevali S. et al. Clinical assessment of asthma severity partially corresponds to sputum inflammation. Respir. Med. 2004; 98 (2): 184–193.

33. Fleming L., Wilson N., Regamey N., Bush A. Use of sputum eosinophil counts to guide management in children with severe asthma. Thorax. 2012; 67 (3): 193–198.

34. Fabbri L., Romagoli M., Corbetta L. et al. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease. Am. J. Crit. Care Med. 2003; 167: 418–424.

35. Wark P.A.B., Johnston S.L., Moric I. et al. Neutrophil degranulation and cell lyses is associated with clinical severity in virus-induced asthma. Eur. Respir. J. 2002; 19: 68–75.

36. Zhang Q., Illing R., Hui Ch.K. et al. Bacteria in sputum of stable severe asthma and increased airway wall thickness. Respir. Res. 2012; 13: 35-42.

37. Horvat J., Starkey M.R., Kim R.Y. et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J. Immunol. 2010; 184: 4159–4169.

38. Wang F., He X.J., Baines K.J. et al. Different inflammatory phenotypes in adult and children with acute asthma. Eur. Resp. J. 2011; 38 (3): 567–574.

39. Fah Y.V. Eosinophilic and neutrophilic inflammation in asthma insights from clinical studies. Allergy. 2010; 2: 10–15.

40. Mohamed N.R., Grany E.A.A., Othman K.M. Analysis of induced sputum in patients with bronchial asthma. Egypt. J. Chest. Dis. Tub. 2014; 63 (1): 21–27.

41. Li A.M., Tsang T.W.T., Chan D.F.Y. et al. Cough frequency in children with mild asthma correlates with sputum neutrophil count. Thorax. 2006; 61: 747–750.

42. Bandyopadhyay A., Roy P.P., Saha K. et al. Usefulness of induced sputum eosinophil count to assess severity and treatment outcome in asthma patients. Lung India. 2013; 30 (2): 117–123.

43. Berry M., Morgan A., Shaw D.E. et al. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax. 2007; 62: 1043–1049.

44. Haldar P., Brighting C.E., Hongadon B. et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N. Engl. J. Med. 2009; 360: 973–984.

45. Fleming L., Tsartsali L., Wilson N. et al. Sputum inflammatory phenotypes re not stable in children with asthma. Thorax. 2012; 67 (8): 675–681.

46. Cosmic L., Liotta F., Maggi E. et al. TH17 cells: new players in asthma pathogenesis. Allergy. 2011; 5: 989–998.

47. Woodruff P.G., Modrek B., Choy D.F. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009; 180 (5): 388–395.

48. Огородова Л.М., Черняк Б.А., Козина О.В. и др. Молекулярно-генетические аспекты различных фенотипов хронической обструктивной болезни легких и бронхиальной астмы. Пульмонология. 2013; 1: 5–11.

49. Grupo de trabajo de GESEPOC. Hacia un nuevo enfoque en tratamiento de la EPOC (GESEPOC). Arch. Bronconeumol. 2011; 47: 379–381.

50. Сочетание хронической обструктивной болезни и бронхиальной астмы: согласительный документ Испанского общества пульмонологов и торакальных хирургов. Пульмонология. 2013; 1: 13–19.

51. Simpson J.L., Powell H., Boyle M.J. et al. Claritrhromycin targets neutrophilic airway inflammation in refractory asthma. Am. J. Respir. Crit. Care Med., 2008,177, 148–155.

52. Iwamoto H., Yokovama A., Shiota N. et al. Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype. Eur. Respir. J. 2008; 31: 1379–1380.

53. Postma D.S., Koppelman G.H. Genetics of asthma: where are we and where do wego. Proc. Am. Thorac. Soc. 2009; 6: 283–287.

54. Miffatt M.F., Gut I.G., Demenais F. et al. A large-scale, Consortium-based genomewide study of asthma. N. Engl. J. Med. 2010; 363: 1211–1221.

55. Manolio T.A., Collins F.S., Cox N.J. et al. Finding the missing heritability of complex diseases. Nature. 2009; 461: 747–753.

56. Чучалин А.Г., Оспельникова А.П., Осипова Г.Л. и др. Роль респираторных инфекций в обострениях бронхиальной астмы. Пульмонология. 2007; 5: 14–18.

57. Белоусов Ю.Б., Чучалин А.Г., Насонов Е.Л. и др. Роль воспаления в клинике внутренних болезней. Русский медицинский журнал. 2001; 3 (12): 487–503

58. Черешнев В.А. Иммунные механизмы воспаления. М.: ГЕОТАР-Медиа; 2002: 30–38.

59. Федосеев Г.Б., ред. Механизмы воспаления бронхов и легких и противовоспалительная терапия. СПб: «Нордмедиздат»; 1998.

60. Ильина Н.И., Гудима Г.О. Иммуноопосредованные воспалительные заболевания. Объединяющая концепция. Российский аллергологический журнал. 2005; 1: 10–16.

61. Федосеев Г.Б., Коровина О.В., Тенигина Н.Г. Комплексная диагностика различных клинико-патогенетических вариантов бронхиальной астмы. Терапевтический архив. 1977; 6: 51–55.

62. Федосеев Г.Б., Хлопотова Г.П. Бронхиальная астма. Л.: Медицина; 1988.

63. Федосеев Г.Б., Трофимов В.И. «Многоликая» бронхиальная астма. Российский аллергологический журнал. 2010; 1: 40–53.

64. Cutovic A., Smith A., Woodcock A. Indoor allergens area primary cause of asthma. Eur. Respir. Rev. 1998; 8 (53): 155–158.

65. Федосеев Г.Б., Трофимов В.И., Елисеева М.В. и др. Психосоматические аспекты бронхиальной астмы: механизмы формирования, особенности диагностики, клиники и лечения. Российский аллергологический журнал. 2009; 3: 26–38.

66. Евсюкова Е.В. Аспириновая астма. В кн.: Федосеев Г.Б., ред. Бронхиальная астма. СПб: Медицинское информационное агентство; 1996: 177–179.

67. Трофимов В.И. Глюкокортикоидная зависимость и резистентность. В кн.: Федосеев Г.Б., ред. Бронхиальная астма. СПб: Медицинское информационное агентство; 1996: 161–165.

68. Трофимов В.И., Кагарлицкая В.А., Дизовариальные нарушения при бронхиальной астме. В кн.: Федосеев Г.Б., ред. Бронхиальная астма. СПб: Медицинское информационное агентство; 1996: 165–167.

69. Дидур М.Д. Астма физического усилия. В кн.: Федосеев Г.Б., ред. Бронхиальная астма. СПб: Медицинское информационное агентство; 1996: 184–186.

70. Гембицкий Е.В., Алекссеев В.Г., Печатников Л.М. и др. Бронхиальная астма в пожилом и старческом возрасте. Терапевтический архив. 1984; 56 (3): 16–19.

71. Жихарев С.С. Субклеточные механизмы в регуляции проходимости бронхов. В кн.: Федосеев Г.Б., Жиронкин А.Г., ред. Физиологические и патофизиологические механизмы проходимости бронхов. Л.: Наука; 1984: 180–210.

72. Минеев В.Н. Выраженный адренергический дисбаланс. В кн.: Федосеев Г.Б., ред. Бронхиальная астма. СПб: Медицинское информационное агентство; 1996: 177–179.

73. Паттерсон Р., Греммер JI.K., Гринбергер П.А. Бронхиальная астма. В кн.: Аллергические болезни. Диагностика и лечение. Пер. с англ. Чучалин А.Г., ред. М.: ГОЭТАР-Медиа; 2000: 486–573.

74. Емельянов А.В. Аутоиммунная астма. В кн.: Федосеев Г.Б., ред. Бронхиальная астма. СПб: Медицинское информационное агентство; 1996: 160–161.


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For citations:


Fedoseev G.B., Trofimov V.I., Shaporova N.L., Aleksandrin V.A., Filippova N.A., Kryakunov K.N. Searching the truth: what is bronchial asthma? PULMONOLOGIYA. 2015;25(1):5-18. (In Russ.) https://doi.org/10.18093/0869-0189-2015-25-1-5-18

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