Immune deficiency syndrome in children with perinatal HIV-infection and tuberculosis
https://doi.org/10.18093/0869-0189-2014-0-6-60-64
Abstract
Aim. This study was performed in order to investigate clinical spectrum of immune deficiency syndrome (IDS) and its influence on the course of tuberculosis in HIV mono-infected or co-infected children. Methods. We analyzed historical data and carried out a randomized prospective study involving 125 children. Results. Infection-related IDS was diagnosed in all HIV-mono-infected children, children with HIV-associated tuberculosis and children with tuberculosis, i.e. in one third of the cases. Children with HIV and tuberculosis co-infection frequently had a history of respiratory diseases, such as recurrent tracheobronchitis and recurrent pneumonia, and extended and / or complicated pulmonary tuberculosis. Conclusion. Therefore, infection-related IDS could be a predictor of tuberculosis in children and should be considered in diagnosis of HIV monoinfection and co-infection together with other clinical and historical data.
About the Authors
S. N. Shugaeva
State Institution Irkutsk State Medical Postgraduate Academy: 100, Yubileyny, Irkutsk, 664049, Russia
Russian Federation
Russian Federation
PhD, Associate Professor of Department of Tuberculosis, State Budget Educational Institution of Аdditional Еducation "Irkutsk Medical Academy of Postgraduate Training", Irkutsk, Russia; tel.: (914) 924-34-30
A. G. Petrova
State Institution Irkutsk State Medical University: 1, Krasnogo Vosstaniya, Irkutsk, 664003, Russia
Russian Federation
Russian Federation
MD, Professor of the Department of Pediatric Infectious Diseases, State Budget High-Level Educational Institution "Irkutsk State Medical University"; tel.: (914) 888-90-05
S. V. Smirnova
Federal Institute of Medical Problems of the North, Northern Department of Russian Academy of Medical Science: 3G, Partizana Zsheleznyaka ul., Krasnoyarsk, 660022, Russia
Russian Federation
Russian Federation
MD, Professor, Deputy Director for Science, Head of Department of Clinical Immunology and Cell Technologies, Federal State Budget institution "Scientific Research Institute of Medical Problems of the North", Northern Department of Russian Academy of Medical Science, Krasnoyarsk, Russia; tel.: (3912) 28-06-81
E. V. Moskaleva
State Institution Irkutsk State Medical University: 1, Krasnogo Vosstaniya, Irkutsk, 664003, Russia
Russian Federation
Russian Federation
PhD, Assistant Lecturer of the Department of Pediatric Infectious Diseases, State Budget High-Level Educational Institution "Irkutsk State Medical University"; tel.: (917) 910-20-25
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For citations:
Shugaeva S.N., Petrova A.G., Smirnova S.V., Moskaleva E.V. Immune deficiency syndrome in children with perinatal HIV-infection and tuberculosis. PULMONOLOGIYA. 2014;(6):60-64. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-6-60-64
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