Non-drug therapy of tuberculosis: from Chekhov to the present day
https://doi.org/10.18093/0869-0189-2025-35-3-423-432
Abstract
The success of antibacterial therapy has overshadowed non-drug pathogenetic methods of tuberculosis treatment. However, the growth of drug resistance requires not only the search for new reserve drugs for the treatment of the disease but also the active study and conscious use of longknown non-drug methods.
The aim of the work was to familiarize doctors with the main directions of non-drug pathogenic treatment and to create motivation for a more detailed study of individual directions and their implementation in clinical practice.
Conclusion. The use of most non-drug treatment methods is justified from the point of view of modern understanding of the pathogenesis of the disease. Evidence criteria have to be developed for a more complete study of their effectiveness and subsequent inclusion in clinical guidelines.
About the Authors
S. V. SmerdinRussian Federation
Sergey V. Smerdin - Doctor of Medicine, Professor, Chief Physician, Moscow Regional Clinical Tuberculosis Dispensary; Head of the Department of Phthisiology, Moscow Regional Research and Clinical Institute (“MONIKI”).
Ul. Dubki 7, Zdravnitsa, Mytishchi, Moscow region, 141132; ul. Shchepkina 61/2, Moscow, 129110; tel.: (496) 588-41-29
Competing Interests:
The author declares that there is no conflict of interest
M. V. Vershinina
Russian Federation
Maria V. Vershinina - Doctor of Medicine, Phthisiologist, Pulmonologist, Moscow Regional Clinical Tuberculosis Dispensary; Professor, Department of Phthisiology, Moscow Regional Research and Clinical Institute (“MONIKI”).
Ul. Dubki 7, Zdravnitsa, Mytishchi, Moscow region, 141132; ul. Shchepkina 61/2, Moscow, 129110; tel.: (496) 588-41-29
Competing Interests:
The author declares that there is no conflict of interest
M. A. Plekhanova
Russian Federation
Maria A. Plekhanova - Doctor of Medicine, Deputy Chief Physician for Scientific Work, State Budgetary Healthcare Institution of the Moscow Region “Moscow Regional Clinical Tuberculosis Dispensary”; Professor, Department of Phthisiology, Moscow Regional Research and Clinical Institute (“MONIKI”).
Ul. Dubki 7, Zdravnitsa, Mytishchi, Moscow region, 141132; ul. Shchepkina 61/2, Moscow, 129110; tel.: (496) 588-41-29
Competing Interests:
The author declares that there is no conflict of interest
References
1. Ministry of Health of the Russian Federation [Tuberculosis in adults: Guidelines]. 2024. Available at: https://cr.minzdrav.gov.ru/preview-cr/16_3 [Accessed: March 30, 2025] (in Russian).
2. Ponomarenko G.N., ed. [Physical therapy]. 3rd Edn. Moscow: GEOTAR-Media; 2023 (in Russian).
3. Volskaya E.A. [Patient compliance. An overview of research trends]. Remedium. 2013; (11): 6–15. Available at: https://cyberleninka.ru/article/n/patsientskiy-komplaens-obzor-tendentsiy-v-issledovaniyah/viewer (in Russian).
4. Kumar Panda U., Ra D., Swaroop Sahoo S. et al. Interplay between tuberculosis, mental illness, and treatment compliance: an integrative literature review. Indian J. Tuberc. 2024; 71 (3): 353–357. DOI: 10.1016/j.ijtb.2023.10.004.
5. Pourali F., Khademloo M., Abedi S. et al. Relationship between smoking and tuberculosis recurrence: a systematic review and meta-analysis. Indian J. Tuberc. 2023; 70 (4): 475–482. DOI: 10.1016/j.ijtb.2023.04.010.
6. Koretskaya N.M., Narkevich A.N., Narkevich A.A., Grin E.N. [Tuberculosis and tobacco smoking: a risk of development and specific features in smoking patients]. Pul'monologiya. 2017; 27 (1): 51–55. DOI: 10.18093/0869-0189-2017-27-1-51-55 (in Russian).
7. Sakharova G.M., Antonov N.S., Mikhailova Yu.V., Peredelskaya M.Yu. [Guideline on medical care for patients with chronic obstructive pulmonary disease and other lung obstructive diseases during tobacco smoking withdrawal]. Pul'monologiya. 2019; 29 (3): 327–333. DOI: 10.18093/0869-0189-2019-29-3-327-333 (in Russian).
8. Chekhov A.P. [Letter to Tarakhovsky A.B., November 26, 1899. Yalta]. In: Chekhov A.P. [Letters]. Vol. 8, 1899. Moscow: Nauka; 1980: 313–315 (in Russian).
9. Perelman M.I. [Phthisiology. Guidelines]. Moscow: GEOTAR-Media; 2007. Available at: https://www.rosmedlib.ru/book/ISBN9785970404904.html (in Russian).
10. Tutelyan V.S., Kaganov B.S., Pogozheva A.V. et al. [Dietary therapy of tuberculosis patients: Guidelines]. M.; 2006. Available at: https://textarchive.ru/c-2089970-pall.html (in Russian).
11. Chekhov A.P. [Letter to Suvorin A.S., October 14, 1888, Moscow]. In: Chekhov A.P. [Letters]. Vol. 3, October 1888 ‒ December 1889. Moscow: Nauka; 1976: 28–30 (in Russian).
12. Mukharlyamov F.Yu., Sycheva M.G., Rassulova M.A., Razumov A.N. [Pulmonary rehabilitation: novel programmes and perspectives]. Pul'monologiya. 2013; (6): 99–105. DOI: 10.18093/0869-0189-2013-0-6-99-105 (in Russian).
Supplementary files
Review
For citations:
Smerdin S.V., Vershinina M.V., Plekhanova M.A. Non-drug therapy of tuberculosis: from Chekhov to the present day. PULMONOLOGIYA. 2025;35(3):423-432. (In Russ.) https://doi.org/10.18093/0869-0189-2025-35-3-423-432