The role of the receptor for advanced glycation endproducts (RAGE) in the pathogenesis of asthma
https://doi.org/10.18093/0869-0189-2025-35-1-95-101
Abstract
Now the role of the receptor for advanced glycation endproducts (RAGE) and its isoforms in the pathogenesis of asthma is discussed. The aim was to review national and foreign literature on the role of RAGE in the pathogenesis of asthma. The search was performed in the PubMed and RISC databases. Results. The available literature data allow considering RAGE as a possible biomarker of the disease or to use the ligand-RAGE axis as a target for therapeutic intervention. Conclusion. This subject requires further experimental and clinical studies for the possible development of new approaches to the management of patients with asthma.
About the Authors
L. N. Sorokina
Federal State Budgetary Educational Institution of Higher Education “Pavlov First Saint Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Lada N.Sorokina, Doctor of Medicine, Professor, Professor, Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic
ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-68-98
Competing Interests:
No conflict of interest was declared by the authors.
V. N. Mineev
Federal State Budgetary Educational Institution of Higher Education “Pavlov First Saint Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Valery N. Mineev, Doctor of Medicine, Professor, Professor, Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic
ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-67-46
Competing Interests:
No conflict of interest was declared by the authors.
A. S. Pavlova
Federal State Budgetary Educational Institution of Higher Education “Pavlov First Saint Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Anastasiia S. Pavlova, Assistant, Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic
ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-68-98
Competing Interests:
No conflict of interest was declared by the authors.
V. I. Trofimov
Federal State Budgetary Educational Institution of Higher Education “Pavlov First Saint Petersburg State Medical University”, Ministry of Healthcare of Russian Federation
Russian Federation
Competing Interests:
Russian Federation
Vasiliy I. Trofimov, Doctor of Medicine, Professor, Head of Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic
ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-67-46
Competing Interests:
No conflict of interest was declared by the authors.
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For citations:
Sorokina L.N., Mineev V.N., Pavlova A.S., Trofimov V.I. The role of the receptor for advanced glycation endproducts (RAGE) in the pathogenesis of asthma. PULMONOLOGIYA. 2025;35(1):95-101. (In Russ.) https://doi.org/10.18093/0869-0189-2025-35-1-95-101
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