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Invasive pulmonary aspergillosis after COVID-19

https://doi.org/10.18093/0869-0189-2024-34-4-569-575

Abstract

Invasive aspergillosis is a disease that occurs mostly in people with a compromised immune system. The most important pathogen is Aspergillus fumigatus (it accounts for about 90% of the patients). The risk group includes patients who have primary and secondary immunodeficiencies, people receiving immunosuppressive therapy, cancer patients, etc. However, the incidence of this disease among COVID-19 (COronaVIrus Disease 2019) patients have been reported recently. The aim of our work is to present a patient with invasive aspergillosis after COVID-19 who was not in a standard risk group and did not receive immunosuppressive therapy. Conclusion. Patients who had COVID-19 are under a risk of developing invasive pulmonary aspergillosis. Therefore, it is important to exclude this disease in a patient with prolonged pneumonia that does not respond to standard therapy.

About the Authors

E. V. Reznik
Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation; Joint Stock Company “MEDSI Group of Companies”; State Budgetary Healthcare Institution of Moscow City “City Clinical Hospital No.31 named after Academician G.M. Savelyeva, Moscow Health Department”
Russian Federation

Elena V. Reznik - Doctor of Medicine, Associate Professor, Head of the Department of Propaedeutics of Internal Diseases, Faculty of Medicine, Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation; Cardiologist, Joint Stock Company “MEDSI Group of Companies”; Physician of Functional Diagnostics, State Budgetary Healthcare Institution of Moscow City “City Clinical Hospital No.31 named after Academician G.M. Savelyeva, Moscow Health Department.

Ostrovityanova ul. 1, Moscow, 117997; Krasnaya Presnya ul. 16, Moscow, 123242; Lobachevskogo ul. 42, Moscow, 119415

Tel.: (499) 936-99-50


Competing Interests:

None



M. D. Iarovoi
Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation

Maksim D. Iarovoi - IV year student, Faculty of Medicine, Federal State Autonomous Educational Institution of Higher Education “N.I.Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation.

Ostrovityanova ul. 1, Moscow, 117997

Tel.: (919) 253-81-41


Competing Interests:

None



Sh. M. Umakhanova
Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation
Russian Federation

Shakhrizat M. Umakhanova - IV year student, Faculty of Medicine, Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation.

Ostrovityanova ul. 1, Moscow, 117997

Tel.: (929) 696-15-14


Competing Interests:

None



S. N. Marshala
Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation; Joint Stock Company “MEDSI Group of Companies”
Russian Federation

Sergey N. Marshala - Head of the Center for Personalized Medicine, Joint Stock Company “MEDSI Group of Companies”; General Practitioner, Rheumatologist, Assistant at the Department of Propaedeutics of Internal Diseases, Faculty of Medicine, Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation.

Ostrovityanova ul. 1, Moscow, 117997; Krasnaya Presnya ul. 16, Moscow, 123242

Tel.: (905) 594-38-22


Competing Interests:

None



A. P. Smirnov
Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation; State Budgetary Healthcare Institution of Moscow City “City Clinic No.212, Moscow Health Department”
Russian Federation

Andrey P. Smirnov - Candidate of Medicine, Chief Freelance Specialist, Moscow Health Department of the Western Administrative District for neurology; Associate Professor, Department of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine, Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation; Neurologist, Physician of Functional Diagnostics, State Budgetary Healthcare Institution of Moscow City “City Clinic No.212, Moscow Health Department”.

Ostrovityanova ul. 1, Moscow, 117997; Solntsevskiy prospekt 11A, Moscow, 119633

Tel.: (495) 934-23-55


Competing Interests:

None



References

1. Ledoux M.P., Herbrecht R. Invasive pulmonary Aspergillosis. J. Fungi (Basel). 2023; 9 (2): 131. DOI: 10.3390/jof9020131.

2. Zakaria A., Osman M., Dabboussi F. et al. Recent trends in the epidemiology, diagnosis, treatment, and mechanisms of resistance in clinical Aspergillus species: a general review with a special focus on the Middle Eastern and North African region. J. Infect. Public. Health. 2020; 13 (1): 1–10. DOI: 10.1016/j.jiph.2019.08.007.

3. Boyer J., Feys S., Zsifkovits I. et al. Treatment of invasive Aspergillosis: how it's going, where it's heading. Mycopathologia. 2023; 188 (5): 667–681. DOI: 10.1007/s11046-023-00727-z.

4. Gangneux J.P., Dannaoui E., Fekkar A. et al. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study. Lancet Respir. Med. 2022; 10 (2): 180–190. DOI: 10.1016/S2213-2600(21)00442-2.

5. WHO fungal priority pathogens list to guide research, development and public health action. Geneva: World Health Organization; 2022. DOI: 10.13140/RG.2.2.31126.63040.

6. Lu L.Y., Lee H.M., Burke A. et al. Prevalence, risk factors, clinical features, and outcome of influenza-associated pulmonary Aspergillosis in critically Ill patients: a systematic review and meta-analysis. Chest. 2024; 165 (3): 540–558. DOI: 10.1016/j.chest.2023.09.019.

7. Ghizlane E.A., Manal M., Abderrahim E.K. et al. Lymphopenia in COVID-19: a single center retrospective study of 589 cases. Ann. Med. Surg. (Lond.). 2021; 69: 102816. DOI: 10.1016/j.amsu.2021.102816.

8. Liu K., Fang Y.Y., Deng Y. et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin. Med. J. (Engl.). 2020; 133 (9): 1025–1031. DOI: 10.1097/CM9.0000000000000744.

9. Bhaskar S., Sinha A., Banach M. et al. Cytokine storm in COVID-19-immunopathological mechanisms, clinical considerations, and therapeutic Approaches: The REPROGRAM Consortium Position Paper. Front. Immunol. 2020; 11: 1648. DOI: 10.3389/fimmu.2020.01648.

10. Lucas R.M., Liu L., Curson J.E.B. et al. SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell. Rep. 2021; 36 (10): 109662. DOI: 10.1016/j.celrep.2021.109662.

11. Chang T., Yang J., Deng H. et al. Depletion and dysfunction of dendritic cells: Understanding SARS-CoV-2 infection. Front. Immunol. 2022; 13: 843342. DOI: 10.3389/fimmu.2022.843342.

12. Salazar F., Bignell E., Brown G.D. et al. Pathogenesis of respiratory viral and fungal coinfections. Clin. Microbiol. Rev. 2022; 35 (1): e0009421. DOI: 10.1128/CMR.00094-21.

13. Weiss E., Schlegel J., Terpitz U. et al. Reconstituting NK cells after allogeneic stem cell transplantation show impaired response to the fungal pathogen Aspergillus fumigatus. Front. Immunol. 2020; 11: 2117. DOI: 10.3389/fimmu.2020.02117.

14. Schmidt S., Luckowitsch M., Hogardt M., Lehrnbecher T. Natural killer cell line NK-92-mediated damage of medically important fungi. J. Fungi (Basel). 2021; 7 (2): 144. DOI: 10.3390/jof7020144.

15. Soe W.M., Lim J.H.J., Williams D.L. et al. Using expanded natural killer cells as therapy for invasive Aspergillosis. J. Fungi (Basel). 2020; 6 (4): 231. DOI: 10.3390/jof6040231.

16. Morton C.O., Griffiths J.S., Loeffler J. et al. Defective antifungal immunity in patients with COVID-19. Front. Immunol. 2022; 13: 1080822. DOI: 10.3389/fimmu.2022.1080822.

17. Yakovlev S.V., Briko N.I., Sidorenko S.V., Protsenko D.N., eds. [The SCAT program (Antimicrobial Therapy Control Strategy) in the provision of inpatient medical care: Russian clinical guidelines]. Moscow: Pero; 2018. Available at: https://antimicrob.net/wp-content/uploads/skat.pdf?ysclid=lxm7jn9ns3872135974 [Accessed: February 16, 2024] (in Russian).


Supplementary files

Review

For citations:


Reznik E.V., Iarovoi M.D., Umakhanova Sh.M., Marshala S.N., Smirnov A.P. Invasive pulmonary aspergillosis after COVID-19. PULMONOLOGIYA. 2024;34(4):569-575. (In Russ.) https://doi.org/10.18093/0869-0189-2024-34-4-569-575

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ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)