Интерстициальные заболевания легких у пожилых


https://doi.org/10.18093/0869-0189-2014-0-4-91-99

Полный текст:


Аннотация

Интерстициальные заболевания легких у пожилых представляют одну из важных проблем геронтологической пульмонологии. Наибольшее клиническое значение имеет идиопатический легочный фиброз, частота которого возрастает по мере старения и у пожилых лиц превышает таковую в более молодых возрастных группах. Приводятся эпидемиологические данные, обсуждаются вопросы патогенеза заболевания с учетом его развития на фоне сенильного легкого, особенности течения и прогноза в условиях старческой полиморбидности, диагностики с акцентом на наиболее информативные и безопасные методы, а также различные способы лечения в расчете на их патогенетическое действие и переносимость.


Об авторе

Л. И. Дворецкий
ГБОУ ВПО "Первый Московский государственный медицинский университет им. И.М.Сеченова" Минздрава России
Россия

д. м. н., профессор, зав. кафедрой госпитальной терапии № 2 лечебного факультета ГБОУ ВПО "Первый МГМУ им. И.М.Сеченова" Минздрава России; тел.: (499) 2485305



Список литературы

1. King Jr T.E., Collard Н., Richeldi L. Preface. Clin. Chest Med. 2012; 33 (1): 23.

2. Илькович М.М. Диссеминированные заболевания легких. М.: ГЭОТАР; 2011. / Il'kovich M.M., ed. Disseminated Lung Diseases. [Disseminirovannye zabolevaniya legkikh]. Moscow: GEOTAR; 2011 (in Russian).

3. Капустина В.А, Овчаренко С.И. Эволюция классификации интерстициальных заболеваний легких. Что нового дает пересмотр классификации 2012 года? Consilium Medicum. 2013;15 (3): 33–35. / Kapustina V.A., Ovcharen' ko S.I. Evolving classification of interstitial lung disease. What is new in the revised classification of 2012? Consilium Medicum. 2013; 15 (3): 33–35 (in Russian).

4. Черняев А.Л., Самсонова М.В. Идиопатическая интерстициальная пневмония – классификация и патологическая анатомия. Атмосфера. Пульмонология и аллергология. 2013; 2: 51–56. / Chernyaev A.L., Samsonova M.V. Idiopathic interstitial pneumonia: classification and pathologic anatomy. Atmosfera. Pul'monologiya i allergologiya. 2013; 2: 51–56 (in Russian).

5. American Thoracic Society / European Respiratory Society. International multidisciplinary сonsensus сlassification of the idiopathic interstitial pneumonias. Am. J. Respir. Crit. Care Med. 2002; 165: 277.

6. Katzenstein A.L., Mukhopadhyay S., Myers J. Diagnosis of usual interstitial pneumonia and distinction from other fibrosing interstitial lung diseases. Hum. Pathol. 2008; 39: 1275.

7. Fernandez Perez E.R., Daniels C.E., Schroeder D.R. et al. Incidence, prevalence, and clinical course of idiopathic pulmonary fibrosis: a populationbased study. Chest. 2010; 137:129–137.

8. American Thoracic Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. American Thoracic Society (ATS), and the European Respiratory Society (ERS). Am. J. Respir. Crit. Care Med. 2000; 16: 1646–1664.

9. Raghu G., Weycker D., Edelsberg J. et al. Incidence and prevalence of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2006; 174: 810–816.

10. Coultas D.B., Zumwalt R.E., Black W.C., Sobonya R.E. The epidemiology of interstitial lung diseases. Am. J.Respir. Crit. Care Med 1994; 150: 967–972.

11. Gribbin J., Hubbard R.B., Le Jeune I. et al. Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax. 2006; 61: 980–985.

12. Olson A.L., Swigris J.J., Lezotte D.C. et al. Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003. Am. J. Respir. Crit. Care Med. 2007; 176: 277–284.

13. Castriotta R.J., Eldadah B.A., Foster М.W. еt al. Workshop on idiopathic pulmonary fibrosis in older adults. Chest. 2010; 138 (3): 693–703.

14. Dyer C.A., Stockley R.A. The aging lung. Rev. Clin. Gerontol. 2006; 16: 99–111.

15. Dyer C. The interaction of ageing and lung disease. West. Engl. Med. J. 2011; 110 (1): 3.

16. Garantziotis S., Schwartz D.A. Hostenvironment interac tions in pulmonary fibrosis. Semin. Respir. Crit. Care Med. 2006; 27: 574–580.

17. Taskar V.S., Coultas D.B. Is idiopathic pulmonary fibrosis an environmental disease? Proc. Am. Thorac. Soc. 2006; 3: 293–298.

18. Vassallo R., Ryu J.H. Smokingrelated interstitial lung diseases. Clin. Chest Med. 2012; 33: 165–178.

19. Cerri S., Spagnolo P., Luppi F. et al. Smokingrelated interstitial lung disease. In: Cordier JF. (ed.). Orphan Lung Diseases. Eur. Respir. Soc. Monograph. 2011; 54: 282–300.

20. Xu J., Gonzalez E.T., Iyer S.S. et al. Use of senescence accelerated mouse model in bleomycininiduced lung injurysuggests that bone marrowderived cells can alter the out come of lung injury in aged mice. J. Gerontol. 2009; 64A: 731–739.

21. Lopez'Diazguerrero N.E., Luna'Lopez A., Gutierrez'Ruiz M.C. et al. Susceptibility of DNA to oxidative stressors in young and aging mice. Life Sci. 2005; 77: 2840–2854.

22. Zhang H.J., Doctrow S.R., Oberley L.W., Kregel K.C. Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermiainduced liver HSP70 expression with aging. J. Appl. Physiol. 2006; 100: 1385–1391.

23. Cuervo A.M. Autophagy and aging: keeping that old broom working. Trends Genet. 2008; 24: 604–612.

24. Delaunois M.S. Mechanisms in pulmonary toxicology. Clin. Chest Med. 2004; 25: 1–14.

25. Lawson W.E., Loyd J.E. The genetic approach in pulmonary fibrosis: can it provide clues to this complex disease? Proc. Am. Thorac. Soc. 2006; 3: 345–349.

26. Garcia C.K., Raghu G. Inherited interstitial Lung Disease. Clin. Chest Med. 2004; 25: 421–433.

27. Hocher B., Schwarz A., Fagan K.A. et al. Pulmonary fibrosis and chronic lung inflammation in ET1 transgenic mice. Am. J. Respir. Cell Mol. Biol. 2000; 23: 19–26.

28. Kulasekaran P., Scavone C.A., Rogers D.S. et al. Endothelin1 and transforming growth factor1 independently induce fibroblast resistance to apoptosis via AKT activation. Am. J. Respir. Cell Mol. Biol. 2009; 41: 484.

29. Meyer K.C. Interstitial lung disease in the elderly: pathogen esis, diagnosis and management. Sarcoidos. Vasculit. Diffuse Lung Dis. 2011; 28: 3–17.

30. Collins K., Mitchell J.R. Telomerase in the human organism. Oncogene. 2002; 21: 564–579.

31. Liu T., Hu B., Chung M.J. et al. Telomerase regulation of myofibroblast differentiation. Am. J. Respir. Cell Mol. Biol. 2006; 34: 625–633.

32. Thannickal V.J., Loyd J.E. Idiopathic pulmonary fibrosis: a disorder of lung regeneration? Am. J. Respir. Crit. Care Med. 2008; 178: 663–665.

33. Alder J.K., Chen J.J., Lancaster L. et al. Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc. NatlAcad. Sci. USA. 2008; 105: 13051–13056.

34. Armanios M.Y., Chen J.J., Cogan J.D. et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N. Engl. J. Med. 2007; 356: 1317–1326.

35. Mu X.C., Staiano'Coico L., Higgine P.J. Increased transcription and modified growth statedependent expression of the plasminogen activator inhibitor type1 gene characterize the senescent phenotype in human diploid fibroblasts. J. Cell. Physiol. 1998; 174: 90–98.

36. Garcia'Sancho C., Buendia'Roldan I., Fernandez'Plata M.R. et al. Familial pulmonary fibrosis is the strongest risk factor for idiopathic pulmonary fibrosis. Respir. Med. 2011; 105: 1902–1907.

37. Meyer K.C. Management of interstitial lung disease in elderly patients. Curr. Opin. Pulm. Med. 2012; 18 (5): 483–492.

38. Griffith K.A., Sherrill D.L., Siegel E.M. et al. Predictors of loss of lung function in the elderly: the Cardiovascular Health Study. Am. J. Respir. Crit. Care Med. 2001; 1631: 61–68.

39. Roversi P., Pistolesi M., Fabbri L.M. Il mito dell' enfisema senile. In: 49° Congresso Nazionale la geriatria nel servizio sanitario nazionale. Firenze, 3/7 november 2004. Firenze; 2004.

40. Hunninghake G., Lynch D., Galvin J. et al. Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia. Chest. 2003; 124: 1215–1223.

41. Lynch D.A., Travis W.D., Muller N.L. et al. Idiopathic interstitial pneumonias: CT features. Radiology. 2005; 236: 10–21.

42. Copley S.J., Wells A.U., Hawtin K.E. et al. Lung morphology in the elderly: comparative CT study of subjects over 75 years old versus those under 55 years old. Radiology. 2009; 251 (2): 566–573.

43. Fell C.D., Martinez F.J., Liu L.X. et al. Clinical predictors of a diagnosis of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2010; 181: 832–837.

44. Collard H.R. The age of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2010; 181 (8): 771–772.

45. Selman M., Pardo A., Barrera L. et al. Gene expression profiles distinguish idiopathic pulmonary fibrosis from hyper sensitivity pneumonitis. Am. J. Respir. Crit. Care Med. 2006; 173: 188–198.

46. Schmidt S.L., Sundaram B., Flaherty K.R. Diagnosing fibrotic lung disease: when is highresolution computed tomography sufficient to make a diagnosis of idiopathic pulmonary fibrosis? Respirology. 2009; 14: 934–939.

47. Kreider M.E., Hansen'Flaschen J., Ahmad N.N. et al. Coomplications of videoassisted thoracoscopic lung biopsyin patients with interstitial lung disease. Ann. Thorac Surg. 2007; 83: 1140–1145.

48. Lettieri C.J., Veerappan G.R., Helman D.L. et al. Outcomes and safety of surgical lung biopsy for interstitial lung disease. Chest. 2005; 127: 1600–1605.

49. Kayatta M., Hammel J., Staton G. et al. Surgical biopsy for diagnosis of interstitial lung disease is superior to high resolution CT imaging. Chest. 2012; 142: 4.

50. Katzenstein A.L., Zisman D.A., Litzky L.A. et al. Usual interstitial pneumonia: histologic study of biopsy and explant specimens. Am. J. Surg. Pathol. 2002; 26: 1567–1577.

51. Radhu G., Collard H., Egan J. et al. An official ATS / ERS /JRS / ALAT statement: Idiopathic pulmonary fibrosis: Evidencebased guidelines for diagnosis and treatment. Am. J. Respir. Crit. Care Med. 2011; 183: 788–824.

52. Фомин В.В., Попова Е.Н., Лебедева М.В., Шовская Т.Н. Идиопатический легочный фиброз: близки ли мы к общепринятым стандартам диагностики и лечения? Фарматека. 2012; 5: 10–14. / Fomin V.V., Popova E.N., Lebedeva M.V., Shovskaya T.N. Idiopathic pulmonary fibrosis: did we approach to worldwide standards of diagnosis and treatment? Farmateka. 2012; 5: 10–14 (in Russian).

53. Flaherty K.R., King T.E. Jr, Raghu G. et al. Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis? Am. J. Respir. Crit. Care Med. 2004; 170: 904–910.

54. Enomoto T., Usuki J., Azuma A. et al. Diabetes mellitus may increase risk for idiopathic pulmonary fibrosis. Chest. 2003; 123 (6): 2007–2011.

55. Gribbin J., Hubbard R., Smith C. Role of diabetes mellitusand gastrooesophageal reflux in the aetiology of idiopathic pulmonary fibrosis. Respir. Med. 2009; 103 (6): 927–931.

56. Garcia'Sancho Figueroa M.C., Carrillo G., Perez'Padilla R. et al. Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A casecontrol study. Respir. Med. 2009; 104 (2): 305–309.

57. Lancaster L.H., Mason W.R., Parnell J.A. et al. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest. 2009; 136 (3): 772–778.

58. Zisman D.A., Kawut S.M., Lederer D.J. et al. Serum albumin concentration and waiting list mortality in idiopathic interstitial pneumonia. Chest. 2009; 135 (4): 929–935.

59. Kizer J.R., Zisman D.A., Blumenthal N.P. et al. Association between pulmonary fibrosis and coronary artery disease. Arch. Intern. Med. 2004; 164 (5): 551–556.

60. Raghu G., Freudenberger T.D., Yang S. et al. High prevalence of abnormal acid gastrooesophageal reflux in idiopathic pulmonary fibrosis. Eur. Respir. J. 2006; 271: 136–142.

61. Raghu G., Yang S.T., Spada C.A. et al. Sole treatment of acidgastroesophageal reflux in idiopathic pulmonary fibrosis: a case series. Chest. 2006; 129 (3): 794–800.

62. Linden P.A., Gilbert R.J., Yeap B.Y. et al. Laparoscopic fundoplication in patients with endstage lung disease awaitingtransplantation. J. Thorac. Cardiovasc. Surg. 2006; 131 (2): 438–446.

63. Martinez F.J., Safrin S., Weycker D. et al. The clinical course of patients with idiopathic pulmonary fibrosis. Ann. Intern. Med. 2005; 142: 963–967.

64. Brown K.K., Raghu G. Medical treatment for pulmonary fibrosis: current trends, concepts, and prospects. Clin. Chest Med. 2004; 25: 759–772.

65. Kim D.S. Acute exacerbation of idiopathic pulmonary fibrosis. Clin. Chest Med. 2012; 33 (1): 59–68.

66. Collard H.R., Moore B.B., Flaherty K.R. et al. Acute exacerbations of idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2007; 176: 636–643.

67. Fell C.D. Idiopathic pulmonary fibrosis: Phenotypes and comorbidities. Clin. Chest Med. 2012; 33 (1): 51–57.

68. Panos R.J., Mortenson R.L., Nicolli S.A. et al. Clinical deterioration in patients with idiopathic pulmonary fibrosis: cause and assessment. Am. J. Med. 1990; 8: 396–404.

69. Nathan S.D., Shlobin O.A., Ahmad S. et al. Serial development of pulmonary hypertension in patients with idiopathic pulmonary fibrosis. Respiration. 2008; 76 (3): 288–294.

70. Zisman D.A., Karlamangla A.S., Ross D.J. et al. Highresolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis. Chest. 2007; 132 (3): 773–779.

71. Lettieri C.J., Nathan S.D., Barnett S.D. et al. Prevalence and outcomes of pulmonary arterial hypertension in advanced idiopathic pulmonary fibrosis. Chest. 2006; 129 (3): 746–752.

72. Nadrous H.F., Pellikka P.A., Krowka M.J. et al. Pulmonary hypertension in patients with idiopathic pulmonary fibrosis. Chest. 2005; 128 (4): 2393–2399.

73. Cottin V., Le Pavec J., Prevot G. et al. Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome. Eur. Respir. J. 2010; 351: 105–111.

74. Mejia M., Carrillo G., Rojas'Serrano J. et al. Idiopathic pulmonary fibrosis and emphysema: decreased survival associated with severe pulmonary arterial hypertension. Chest. 2009; 136 (1): 10–15.

75. Lee S.J., Lindquist K., Segal M.R., Covinsky K.E. Development and validation of a prognostic index for 4year mortal ity in older adults. J.A.M.A. 2006; 295 (7): 801–808.

76. Lederer D.J., Arcasoy S.M., Wilt J.S. et al. Sixminutewalk distance predicts waiting list survival in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 2006; 174 (6): 659–664.

77. Mehta K.M., Yaffe K, Langa K.M. et al. Additive effects of cognitive function and depressive symptoms on mortality in elderly communityliving adults. J. Gerontol. Biol. Sci. Med. 2003; 58 (5): M461–M467.

78. Ferreira A., Garvey C., Connors G.L. et al. Pulmonary rehabilitation in interstitial lung disease: benefits and predictors of response. Chest. 2009; 135: 442–447.

79. Nishiyama O., Kondoh Y., Kimura T. et al. Effects of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis. Respirology. 2008; 13: 394–399.

80. Collard H.R., King T.E. Jr. Demystifying idiopathic interstitial pneumonia. Arch. Intern. Med. 2003; 163: 17–29.


Дополнительные файлы

Для цитирования: Дворецкий Л.И. Интерстициальные заболевания легких у пожилых.  Пульмонология. 2014;(4):91-99. https://doi.org/10.18093/0869-0189-2014-0-4-91-99

For citation: Dvoretskiy L.I. Interstitial lung disease in elderly. Russian Pulmonology. 2014;(4):91-99. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-4-91-99

Просмотров: 815

Обратные ссылки

  • Обратные ссылки не определены.


ISSN 0869-0189 (Print)
ISSN 2541-9617 (Online)