The assessment of efficacy and safety of ditec, berotec and disodium chromoglycate metered dose inhalers
Abstract
29 COPD patients with reversible airway obstruction (the increase in FEVi after 2 puffs of berotec was no less than 15 % from the baseline value) underwent the study. The onset of bronchodilating action after 1 puff of ditec was marked in 3— 5 minutes with maximum being achieved in 20— 30 minutes after the inhalation. The overall duration of action was 4 to 5 hours. The bronchodilating properties of ditec were similar to berotec ones. There was no significant difference in FEVi and FVC com pared to baseline values after disodium chromoglycate inhalation. The protective effect against exercise-induced bronchoconstriction was marked in 7 patients (24,4 % ) two hours after the inhalation of ditec. The same effect after berotec inhalation was marked only in 4 patients. The addition of ditec to the long-lasting treatm ent of patients with intrinsic bronchial asthma and steroid-dependent bronchial asthma resulted in improvement of their clinical condition and led to the opportunity of decreasing the supporting dosage of prednisone.
About the Authors
V. G. Kukes
Московская медицинская академия им. И. М. Сеченова
Russian Federation
Russian Federation
A. N. Tzoy
Московская медицинская академия им. И. М. Сеченова
Russian Federation
Russian Federation
L. N. Gavrilenko
Московская медицинская академия им. И. М. Сеченова
Russian Federation
Russian Federation
S. F. Sadovnikova
Московская медицинская академия им. И. М. Сеченова
Russian Federation
Russian Federation
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Review
For citations:
Kukes V.G., Tzoy A.N., Gavrilenko L.N., Sadovnikova S.F. The assessment of efficacy and safety of ditec, berotec and disodium chromoglycate metered dose inhalers. PULMONOLOGIYA. 1992;(3):63-68. (In Russ.)
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