Interrelation of delta-F-508 mutation with immunoreactivity features in patients with cystic fibrosis
Abstract
The immunoreactivity was studied in children with cystic fibrosis (CF) and in patients of CF older than 14 years old during exacerbation periods of the disease and after treatment in clinic. Parameters of the humoral and T-cellular immunity, the fagocytic activity of blood monocytes and neutrophyls in carriers of the allele ∆F508 (homozygotes and compound heterozygotes) and in patients with other CF gen mutations were compared.
The carriers of AF508 mutations had the high levels of immunoglobulins A, G, M and of circulating immune complexes (CIC) considerably more often than the ones with other CF gen mutations, that was caused by more frequent colonization of bronchial Ps. aeruginosa and S. aureus. After treatment in majority of homozygotes ∆/∆F508) high levels of IgG and CIC (63 %), the reduction of the fagocytic activity of monocytes (75 %) and FGA-induced blasttransformation (81 %) were remained. In this period, 63 % of patients with CF older than 14 without F508 mutation had the decrease of the number of OKT3+ ymphocytes and 89 % of them showed the weak response on FGA-induction, that can be connected with the more frequent infectioning of these patients by Ps. aeruginosa and S. aureus in comparison with children without ∆F508 allele.
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Review
For citations:
Blinova T.V. Interrelation of delta-F-508 mutation with immunoreactivity features in patients with cystic fibrosis. PULMONOLOGIYA. 1993;(2):56-61. (In Russ.)
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