The effect of tracheal mucous membrane peptides on the development of experimental pulmonary fibrosis
Abstract
The model of bloemycin-induced pulmonary fibrosis was produced in rats to evaluate the effect of tracheal mucous membrane peptides (TMMP) used for prevention of massive proliferation in the interstitial connective tissue in lungs. The application of TMMP reduced the negative consequences of bleomycin administration. The mortality was decreased by three times. The body weight was increased at 52 % of the initial value. Hypertrophy of the right heart ventricle developed in a smaller degree in comparison with untreated rats. The content of the connective tissue in alveolar walls was diminished. It was loose of the connective tissue with non numerous collagen fibers. Ultrastructural studies of bronchoalveolar lavage cells showed great differences of alveolar magrophage populations in two groups of rats — untreated and treated with TMMP. The possible role of alveolar macrophages in the observed effect of TMMP for modulation of fibroplastic process in lungs is discussed.
About the Authors
L. N. Danilov
НИИ Пульмонологии Минздрава РФ
Russian Federation
Russian Federation
E. S. Lebedeva
НИИ Пульмонологии Минздрава РФ
Russian Federation
Russian Federation
N. E. Okuneva
НИИ Пульмонологии Минздрава РФ
Russian Federation
Russian Federation
A. L. Kodjemiakin
НИИ Пульмонологии Минздрава РФ
Russian Federation
Russian Federation
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Review
For citations:
Danilov L.N., Lebedeva E.S., Okuneva N.E., Kodjemiakin A.L. The effect of tracheal mucous membrane peptides on the development of experimental pulmonary fibrosis. PULMONOLOGIYA. 1993;(2):26-30. (In Russ.)
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