Effects of therapy with systemic glucocorticosteroids on endothelial function and hemostasis in patients with infective exacerbation of chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2012-0-2-40-45
Abstract
Summary. Changes in basic parameters of vascular endothelial function and thrombinaemia were analyzed in 111 patients with acute infective exacerbation of COPD upon therapy with systemic steroids. In acute infective exacerbation of COPD, increased levels of endotelin-1 and homocysteine as endothelial dysfunction markers, substantial increase in plasma D-dimer level and changes in thrombocyte aggregation were found. Treatment with systemic steroids led to decreasing in endotelium-1 and D-dimer levels which directly related to C-reactive protein. In stable COPD, high D-dimer level persisted that was considered as thrombogenic and thromboembolic risks in COPD patients with cardiovascular comorbidity.
About the Authors
I. Ya. Tseimakh
ГОУ ВПО "Алтайский государственный медицинский университет Росздрава"
Russian Federation
Russian Federation
A. P. Momot
Алтайский филиал Гематологического научного центра Росздрава
Russian Federation
Russian Federation
G. I. Kostyuchenko
ГУЗ "Алтайская краевая клиническая больница"
Russian Federation
Russian Federation
Yu. A. Filonova
ГОУ ВПО "Алтайский государственный медицинский университет Росздрава"
Russian Federation
Russian Federation
T. A. Kornilova
МУЗ "Городская больница № 5"
Russian Federation
Russian Federation
I. P. Kramar
МУЗ "Городская больница № 5"
Russian Federation
Russian Federation
A. G. Chuchalin
ФГУ "НИИ пульмонологии" ФМБА России
Russian Federation
Russian Federation
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Review
For citations:
Tseimakh I.Ya., Momot A.P., Kostyuchenko G.I., Filonova Yu.A., Kornilova T.A., Kramar I.P., Chuchalin A.G. Effects of therapy with systemic glucocorticosteroids on endothelial function and hemostasis in patients with infective exacerbation of chronic obstructive pulmonary disease. PULMONOLOGIYA. 2012;(2):40-45. (In Russ.) https://doi.org/10.18093/0869-0189-2012-0-2-40-45
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