Calculation of bronchial challenge results: problems and solutions

Abstract

Bronchial challenge is a powerful measure for C O P D differential diagnostics, treatment quality estimation, and action efficacy of various medications. Recently, many estimation ways are proposed and standardised for each bronchial challenge technique. The standard advances strict demand s to the choice of estimation criterias and methodically defined protocol fulfilment. That provides the comparability of test results. However, the current standard restricts the method ability by evidence of bronchial hyperreactivity in patients.
Two year experience of routine evaluation of bronchial hyperreactivity in called for military service and exploration experience of new drugs were the basis of proposed ways to estimation of bronchial challenge results. The new ways allow to extend diagnostic abilities of the method by means of information about current impairment pathogenesis and to open wider the action mechanism of antiasthmatic medications.
The short description of the currently acted standard of nonspecific bronchial challenge method with dosed aerosoles is presented in the article. New estimation parameters are proposed, analysed, and grounded. Advances of new method modifications are illustrated. Practical advices for use are given. The authors hope, that the article will be helpful for physician s and scientists dealt with bronchial hyperreactivity problem and new drug testing.