The analysis of hemoglobin affinity for oxygen and tissue consumption of oxygen
Abstract
The tissue and blood oxygenation estimation with taking into consideration the hemoglobin affinity for oxygen with new parameter pO2-effective use was studied. The calculation algorithm and its program realization for paeO2 and estimation of the dissociation oxyhemoglobin curve (ODC) were produced.
28 patients were examined with the measurement of next parameters of arterial blood: pH, gas composition (paO2 and paCO2), and blood oxygenation (SO2, ctO2). The calculation of paeO2 value and the shift of ODC was carried out. The estimation of oxygen consumption (VO2) was carried out in 11 patients.
The analysis of the obtained data allowed to conclude that paeO2 reflects changes of the hemoglobin affinity for oxygen in such a way, that when affinity is decreased then ODC shift is greater than zero and when the affinity is increased then ODC shift is less than zero. The parameter paeO2 allows to estimate more correctly the blood oxygenation than paO2 in mmHG terms. The correlation with the coefficient 0.8 was found between the value of the DOC shift and oxygen consumption. In the case of the negative ODC shift, the oxygen consumption is decreased, in the case of the positive ODC shift oxygen consumption is increased.
Thus, on the basis of ODC, it is possible to estimate the blood and tissue oxygenation with taking into consideration the hemoglobin affinity for oxygen and, therefore, the respiration of organism in general.
About the Authors
G. M. Sakharova
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
E. A. Gvozdeva
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
V. A. Brajnick
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
O. N. Makretskaya
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
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Review
For citations:
Sakharova G.M., Gvozdeva E.A., Brajnick V.A., Makretskaya O.N., Chuchalin A.G. The analysis of hemoglobin affinity for oxygen and tissue consumption of oxygen. PULMONOLOGIYA. 1994;(1):55-59. (In Russ.)
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