ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ СОВРЕМЕННЫХ МУКОАКТИВНЫХ ПРЕПАРАТОВ В ТЕРАПИИ ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЕГКИХ
Аннотация
При повышении количества (гиперсекреция) и вязкости секрета (дискриния) развивается интралюминальная окклюзия дыхательных путей (ДП) у пациентов с хронической обструктивной болезнью легких (ХОБЛ), кроме того, гиперпродукция бронхиального секрета способствует ухудшению течения заболевания и делает пациента более склонным к инфекциям ДП. Эрдостеин (производное тиола) – новый мукоактивный препарат для терапии больных ХОБЛ, с помощью которого модулируется продукция и состав бронхиального секрета, уменьшается его вязкость и улучшается мукоцилиарный транспорт. Кроме того, эрдостеин обладает антиадгезивной, антиоксидантной и противовоспалительной активностью. По данным проведенных исследований, при длительной поддерживающей терапии эрдостеином (рекомендуемая доза – 600 мг в сутки) при ХОБЛ улучшается клиническая картина, качество жизни больных, уменьшается число обострений ХОБЛ. При обострении ХОБЛ в результате терапии эрдостеином (рекомендуемые дозы 600–900 мг в сутки) уменьшаются симптомы обострения, выраженность местной и системной воспалительной реакции и ускоряется разрешение обострения.
Об авторе
С. Н. Авдеев
ФГБУ "НИИ пульмонологии" ФМБА России: 105077, Россия, Москва, ул. 11-я Парковая, 32, корп. 4
Россия
Россия
д. м. н., профессор, руководитель клинического отдела ФГБУ "НИИ пульмонологии" ФМБА России; тел. / факс: (495) 465-52-64
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Рецензия
Для цитирования:
Авдеев С.Н. ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ СОВРЕМЕННЫХ МУКОАКТИВНЫХ ПРЕПАРАТОВ В ТЕРАПИИ ПАЦИЕНТОВ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ ЛЕГКИХ. Пульмонология. 2014;(2):100-108. https://doi.org/10.18093/0869-0189-2014-0-2-100-108
For citation:
Avdeev S.N. PERSPECTIVES OF NOVEL MUCOACTIVE DRUGS IN THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. PULMONOLOGIYA. 2014;(2):100-108. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-2-100-108
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