Study of association of ACE gene I/D polymorphism with the risk of pulmonary sarcoidosis (with the participation of the Republic of Karelia residents)
https://doi.org/10.18093/0869-0189-2022-32-1-89-94
Abstract
The aim of the study was to analyze the association of I/D polymorphism of angiotensin-converting enzyme (ACE) gene with the risk of pulmonary sarcoidosis in ethnic Russians of the Republic of Karelia.
Methods. The study enrolled 242 individuals, including 112 patients of Russian nationality residing in the Republic of Karelia with confirmed pulmonary sarcoidosis and 130 healthy donors as a control group. The distribution of alleles and genotypes of I/D polymorphism of ACE gene (rs4646994) in these groups was investigated. Alleles of this polymorphic marker were identified by the method of PCR-RFLP.
Results. The comparative analysis showed no statistically significant differences in the distribution of alleles and genotypes of indel locus of ACE gene (rs4646994) between the control group and the group of patients with pulmonary sarcoidosis (χ2 = 0.619; p > 0.05; χ2 = 0.368; p > 0.05, respectively).
Conclusion. I/D polymorphism of ACE gene is not associated with the risk of pulmonary sarcoidosis in ethnic Russians of the Republic of Karelia
Supporting agencies: The research was financed from the federal budget via a state assignment to the Federal State Budgetary Scientific Institution “Federal Research Center” Karelian Scientific Center of the Russian Academy of Sciences (topic No.0218-2019-0077).
About the Authors
I. E. Malysheva
Institute of Biology – a separate subdivision of the Federal State Budgetary Scientific Institution “Federal Research Center” Karelian Research Center of the Russian Academy of Sciences
Russian Federation
Competing Interests:
Russian Federation
Irina E. Malysheva, Candidate of Biology, Senior Researcher, Laboratory of Genetics
ul. Pushkinskaya 11, Petrozavodsk, 185910, Republic of Karelia
tel.: (8142 ) 57-31-07
Competing Interests:
The authors declare no conflict of interest
L. V. Topchieva
Institute of Biology – a separate subdivision of the Federal State Budgetary Scientific Institution “Federal Research Center” Karelian Research Center of the Russian Academy of Sciences
Russian Federation
Competing Interests:
Russian Federation
Ludmila V. Topchieva, Candidate of Biology, Leading Researcher, Laboratoryof Genetics
ul. Pushkinskaya 11, Petrozavodsk, 185910, Republic of Karelia
tel.: (8142) 57-31-07
Competing Interests:
The authors declare no conflict of interest
E. L. Tikhonovich
State Budgetary Healthcare Institution of the Republic of Karelia “Republican hospital named after V.A.Baranov”
Russian Federation
Competing Interests:
Russian Federation
Ella L. Tikhonovich, Candidate of Medicine, Head of Department
ul. Pirogova 3, Petrozavodsk, 185019, Republic of Karelia
tel.: (8142) 76-39-10
Competing Interests:
The authors declare no conflict of interest
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For citations:
Malysheva I.E., Topchieva L.V., Tikhonovich E.L. Study of association of ACE gene I/D polymorphism with the risk of pulmonary sarcoidosis (with the participation of the Republic of Karelia residents). PULMONOLOGIYA. 2022;32(1):89-94. (In Russ.) https://doi.org/10.18093/0869-0189-2022-32-1-89-94
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