Novel findings about calcium regulation meshanisms of oxydative metabolism in phagocytes
Abstract
The role of Ca2+ in intracellular and extracellular generation of reactive oxygen species (ROS) in phagocytes was evaluated. It was shown that Ca2+ deficiency caused by EGTA and riosidine influenses upon extra- and intracellular ROS generation in different ways. Ionofor A 23187 activated the extracellular generation of ROS, but intracellular generation of ROS was reduced completely. Obtained results suggest that calcium ionofors may have antimutagenic effect. The possible reasons for different effects of calcium deficiency on enzyme systems responsible for generation of ROS were discussed.
About the Authors
A. V. Bizjikin
НИИ пульмонологии М3 РФ; Российский государственный медицинский университет
Russian Federation
Russian Federation
Z. F. Charaeva
НИИ пульмонологии М3 РФ; Российский государственный медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Bizjikin A.V., Charaeva Z.F. Novel findings about calcium regulation meshanisms of oxydative metabolism in phagocytes. PULMONOLOGIYA. 1996;(4):60-62. (In Russ.)
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