Effects of troventol on histamine secretion from mast cells
Abstract
In order to investigate the molecular mechanisms of action of anticholinergic agents, the effect of troventol on one of initial chains of bronchospasm – histamine release from mast cell – was assessed. The effect of troventol was compared with atrovent (ipratropium bromide) and atropine. It was found that cells incubation with troventol for 5 min evokes inhibition of histamine release by 47%, and there were no distinctions between placebo and atropine or atrovent. The histamine release from mast cells was caused by abrupt increase in cytosol Ca2+ concentration. Passive Ca2+ uptake velocity was decreased by troventol (56.3%) and by atrovent (28%), atropine had no influence on it. Thus, unlike atrovent and atropine, troventol can inhibit histamine secretion via reduction of cell membrane permeability for Ca2+.
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Review
For citations:
Timofeev A.A. Effects of troventol on histamine secretion from mast cells. PULMONOLOGIYA. 1996;(4):55-56. (In Russ.)
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