Effect of russian ß2–agonists on airway hyperresponsiveness
Abstract
In this study we compared the effect of oral long-acting salbutamol – saltos (6 mg), inhaled salbutamol, salgem (500 mg), or placebo on the airway responsiveness to histamine. Twenty eight patients with mild bronchial asthma in stable state were observed. The study had a double-blind, crossover, placebo-controlled design. The challenge test with hystamine was peformed before and after administration of the studied medications.
The provacative concentration producing a 20% fall in forced expiratory volume in one second was significantly increased after administration of ß2–agonists than of placebo.
We conclude that Russian ß2–agonists have a significant bronchoprotective effect. The duration of bronchoprotective effect for saltos is 9 h, for salgem is 1.5 h.
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Review
For citations:
Cherniak A.V. Effect of russian ß2–agonists on airway hyperresponsiveness. PULMONOLOGIYA. 1996;(4):46-51. (In Russ.)
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